Kelch-like ECH-associated protein 1 is a protein that in humans is encoded by the Keap1 gene. [5] Keap1 has four discrete protein domains. The N-terminal Broad complex, Tramtrack and Bric-à-Brac (BTB) domain contains the Cys151 residue, which …

KEAP1 (Kelch-1ike ECH- associated protein l，)是指 Kelch 样环氧氯丙烷相关蛋白 1，由 Itoh 等 [1] 通过酵 母双杂交方式分离得到的相对分子量为 69 kD的蛋白。 KEAP1 含有 5个结构域，分别为N端结构域NTR（N-terminal region）、干预区IVR（intervening region）、BTB（Broad complex, Tramtrack and Bric-à-Brac）区、双甘氨酸重复区（DGR）和C端结构域C（C-terminal region）TR。 其中DGR（ double glycine repeat）区也叫Kelch区，是Keap1与Nrf2的Neh2 …

The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role in various disease pathologies has become well appreciated, ...

2025年3月30日 · KEAP1 (Kelch Like ECH Associated Protein 1) is a Protein Coding gene. Diseases associated with KEAP1 include Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors and Lung Cancer. Among its related pathways are Class I MHC mediated antigen processing and presentation and Infectious disease.

2022年6月20日 · KEAP1 functions as (i) a substrate adaptor for a Cullin 3 (CUL3)-based E3 ubiquitin ligase that targets NRF2 for ubiquitination and proteasomal degradation, and (ii) a cysteine-based sensor for a myriad of physiological and pharmacological NRF2 activators.

Kelch 样ECH 关联蛋白1（Kelch-like ECH-associated protein 1，Keap1）是E3泛素连接酶的底物识别亚单位，在蛋白质的泛素化修饰中起重要作用。蛋白质的泛素化修饰作为一种重要且复杂的蛋白质翻译后修饰，在自噬和蛋白酶体系统中作为降解信号而被利用。

Keap1是Nrf2的负性调节器，Nrf2是ARE系统的主要效应器。通过负调节Keap1蛋白激活ARE系统可以诱导一系列抗氧化基因的表达，这对预防氧化损伤、炎症和肿瘤的发生非常关键。因此，激活Keap1-Nrf2-ARE系统，对开发抗氧化、抗炎和抗癌药物具有很大价值。

Keap1 is a metalloprotein binding zinc, which modulates the reactivity of Keap1 critical cysteines, thus influencing Nrf2-dependent response . Coordination of zinc by Keap1 may explain how it can react with H 2 O 2 preferentially versus most other protein cysteines under physiological conditions [ 27 ].

2022年5月2日 · keap1-nrf2系统是一个典型的双组分系统: 其中keap1是亲电物的传感器，nrf2是细胞保护基因协同激活的效应体。 在细胞质中，keap1与cullin3 (cul3)形成泛素e3连接酶复合物，并使nrf2多泛素化，进而通过蛋白酶体系统…

KEAP1，即Kelch样ECH相关蛋白1，别名IKBKE抑制因子、Kelch-like protein 19等。 它是一种由KEAP1基因编码的蛋白质，主要在细胞质中发挥作用。 KEAP1的作用机制主要是通过与NRF2蛋白相互作用，促进NRF2的泛素化和蛋白酶体降解，从而抑制NRF2介导的抗氧化应激和代谢调控基因 ...