The kinin–kallikrein system or simply kinin system is a poorly understood hormonal system with limited available research. [1] It consists of blood proteins that play a role in inflammation, [2] blood pressure control, coagulation and pain. Its important mediators bradykinin and kallidin are vasodilators and act on many cell types. Clinical ...

The plasma kallikrein-kinin system (KKS) plays a critical role in human physiology. The KKS encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high molecular weight kininogen (HK).

The kallikrein–kinin system and kinin receptor pathway. The kallikrein–kinin system (KKS) includes tissue and plasma kallikreins acting on low- and high-molecular weight kininogens (LMWK and HMWK), respectively, to produce bioactive kinins, like bradykinin (BK).

The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and mainly tissue and plasma kallikreins.

The kallikrein-kinin system and its components are implicated in multiple neuropathological states, including ischemic stroke, multiple sclerosis, epilepsy, Alzheimer's disease, and TBI, where neuroinflammatory processes contribute distinctly to disease severity (Naffah-Mazzacoratti et …

The kinin-kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of kininogens with the consequent release of bradykinin-related peptides.

2005年1月1日 · The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and …

Since kallikrein was discovered as a vasodilatory substance in human urine, the kallikrein–kinin system (KKS) has been considered to play a physiological role in controlling blood pressure. Gene targeting experiments in mice in which the KKS has ...

The plasma kallikrein-kinin system (KKS) plays a critical role in human physiology. The KKS encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high molecular weight kininogen (HK).

The kallikrein kinin system (KKS) generates a family of bioactive peptides with varying biological activities. These include hydroxylated and nonhydroxylated bradykinin and kallidin (Lys 0 -bradykinin) peptides and their respective carboxypeptidase metabolites, des-Arg 9 -bradykinin and des-Arg 10 -kallidin.

For a considerable period, the tissue kallikrein–kinin system (KKS) has been regarded as one of the main mechanisms controlling systemic and local hemodynamics. In recent years, there has been a...

1995年8月1日 · The last 25 years have produced significant advances in understanding tissue kallikrein-kinin system component structure, localization, and regulation; system abnormalities in disease; and the ability to manipulate components with various stimuli and, most importantly, specific receptor antagonists.

The vasodilatory kallikrein-kinin system (KKS), due to its ubiquitous roles, mediates several of the pathophysiological features of different neurological disorders as well as being implicated in regulating proper brain functions.

2021年3月3日 · The kallikrein kinin system (KKS) consists of serine proteases involved in the production of peptides called kinins, principally bradykinin and Lys-bradykinin (kallidin). The KKS contributes to a variety of physiological processes including inflammation, blood pressure control and coagulation.

The plasma kallikrein–kinin system is involved in shock or inflammation (Colman and Wong, 1979). Intravascular activation of the plasma kallikrein–kinin system triggers hypotension (Katori et al., 1989b), while the activation of this system in the perivascular space causes inflammatory responses (Uchida et al., 1983). Activation of the ...

2023年10月16日 · The kallikrein-kinin system (KKS) is an intricate phenomenon that has evolved to demonstrate wide distribution through all the systems of the body. For instance, blood has a unique kallikrein (PKa) with reported involvement in inflammation and coagulation, the brain has the tissue kallikrein (KLK 1), the prostate has the human glandular KLK 3 ...

The kallikrein-kinin system (KKS) is an intricate endogenous pathway involved in several physiological and pathological cascades in the brain. Due to the pathological effects of kinins in blood vessels and tissues, their formation and degradation are tightly controlled.

The kallikrein kinin system is shown diagrammatically in Figure 1 and indicates the various pathways by which kinin (bradykinin or lysyl bradykinin) can be formed. The intrinsic coagulation-kinin system is depicted on the left, and the tissue kallikrein-kinin pathway on the right.

In humans, the plasma and tissue kallikrein-kinin systems (KKS) generate bradykinin and kallidin peptides, respectively. 2. We established methodology for the measurement of bradykinin and kallidin peptides and their metabolites in order to study the …

1 天前 · The kallikrein-kinin system is involved in inflammation and interacts with the contact activation pathway and the renin-angiotensin system. Kng2 shows the highest expression in the liver and the kidneys, but our study showed a particularly strong induction of Kng2 in the colon at the end of the DSS administration in the DSS7 group.

The kallikrein-kinin system (KKS) is the key proteolytic system participating in control of a wide spectrum of physiological functions and the development of many pathological conditions. This explains great interest in structures, functions and molecular biology …