Kaftrio is a medicine used to treat patients aged 2 years and above who have cystic fibrosis, an inherited disease that has severe effects on the lungs, the digestive system and other organs. Cystic fibrosis can be caused by various mutations (changes) in the gene for a protein called ‘cystic fibrosis transmembrane conductance regulator ...

Elexacaftor/tezacaftor/ivacaftor, sold under the brand names Trikafta and Kaftrio, is a fixed-dose combination medication used to treat cystic fibrosis. [8][9] Elexacaftor/tezacaftor/ivacaftor is composed of a combination of ivacaftor, a chloride channel opener, and elexacaftor and tezacaftor, CFTR modulators. [8]

Kaftrio 是一种包含 Ivacaftor 、 Tezacaftor 和Elexacaftor（依伐卡托-特扎卡福特-依来卡泊）的三重疗法，用于治疗 囊性纤维化 （CF）。 该药物已获准用于12岁及以上的患者，这些患者要么是具有最常见的囊性纤维化致病 F508del突变 的纯合子，要么是携带F508del突变与最小 ...

Read about the triple combination therapy Kaftrio (known as Trikafta in the United States), which combines ivacaftor, tezacaftor and elexacaftor, and find out how it could help to treat people with cystic fibrosis (CF).

Kaftrio is a medicine used to treat patients aged 2 years and above who have cystic fibrosis, an inherited disease that has severe effects on the lungs, the digestive system and other organs. Cystic fibrosis can be caused by various mutations (changes) in the gene for a …

2023年11月23日 · Kaftrio is the latest of these CFTR modulator treatments and consists of a triple treatment combination of ivacaftor, tezacaftor, and elexacaftor. It’s a long term treatment for patients with cystic fibrosis (CF) who have at least one F508del mutation in the CFTR gene—around 90% of people with CF.

Kaftrio tablets are indicated in a combination regimen with ivacaftor for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene (see section 5.1).

临床数据显示， 在6-11岁CF患者中，Kaftrio+ivacaftor方案（Trikafta）治疗可显著改善肺功能、汗液氯化物、呼吸系统症状，安全性和耐受性与12岁及以上患者中的观察结果一致。 这些数据提供了该方案有效治疗6-11岁CF患者的证据。 Vertex全球药物开发和医疗事务执行副总裁兼首席医疗官Carmen Bozic医学博士表示：“今天标志着欧洲CF儿童治疗的一个重要里程碑。 如果获得批准，Kaftrio与ivacaftor的联合方案将为这些年轻的患者群体提供一种新的治疗选择。 Vertex公 …

2023年11月28日 · Kaftrio tablets are indicated in a combination regimen with ivacaftor for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one F508del mutation in the cystic fibrosis transmembrane conductance …

What Kaftrio is and what it is used for. Kaftrio contains three active substances: ivacaftor, tezacaftor and elexacaftor. The medicine helps lung cells to work better in some patients with cystic fibrosis (CF). CF is an inherited condition in which the lungs and the digestive system can become clogged with thick, sticky mucus.