Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. [5] [6] Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7 integrin is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to …

2025年3月30日 · ITGA7 (Integrin Subunit Alpha 7) is a Protein Coding gene. Diseases associated with ITGA7 include Muscular Dystrophy, Congenital, Due To Integrin Alpha-7 Deficiency and Congenital Myopathy 4A, Autosomal Dominant. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Integrin Pathway.

2016年12月7日 · By comparing differentially expressed genes affected by non-CG methylation between tumour and corresponding non-tumour tissues in oesophageal squamous cell carcinoma (OSCC), we find that Integrin...

整联蛋白是由α链和β链组成的异二聚体整合膜蛋白。 它们介导广泛的细胞-细胞和细胞-基质相互作用，因此在细胞迁移、形态发育、分化和转移中发挥作用。 这种蛋白质作为基底膜蛋白层粘连蛋白-1 的受体发挥作用。 它主要在骨骼肌和心肌中表达，并可能参与成肌过程中的分化和迁移过程。 该基因的缺陷与先天性肌病有关。 已经注意到该基因编码不同亚型的可变剪接转录物变体。 [RefSeq 提供，2009 年 2 月] The protein encoded by this gene belongs to the Integrin alpha …

2017年7月6日 · We identified integrin α7 (ITGA7) as a major laminin receptor in GSCs and in primary high-grade glioma specimens. Analyses of mRNA profiles in comprehensive datasets revealed that high ITGA7 expression negatively correlated with survival of patients with both low- and high-grade glioma.

2025年2月8日 · Title: Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as a predictive marker of chemotherapy response. Integrin alpha 7 correlates with poor clinical outcomes, and it regulates cell proliferation, apoptosis and stemness via PTK2-PI3K-Akt signaling pathway in hepatocellular carcinoma.

CircITGA7 regulates malignant phenotypes in bladder cancer cells via targeting miR-330-3p/KLF10 axis. ITGA7 loss drives the differentiation of adipose-derived mesenchymal stem cells to cancer-associated fibroblasts. Integrin alpha7 Mutations Are Associated With Adult-Onset Cardiac Dysfunction in Humans and Mice.

2024年9月17日 · ITGA7 relates to disease risk, pathological feature, treatment response and survival in Ph (-) acute lymphoblastic leukemia. Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as …

ITGA7的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为由该基因编码的蛋白质属于整合素链家族。 整合素是一个α链和一个β链组成的异二聚体整合膜蛋白。 它们介导细胞 - 细胞和细胞 - 基质相互作用的宽光谱，从而起到在细胞迁移，形态发育，分化和转移的作用。 该蛋白质的功能，作为基底膜蛋白层粘连蛋白-1的受体。 它是主要表达在骨骼肌和心肌和肌形成过程中可能参与了分化和迁移的过程。 在这个基因的缺陷先天性肌病相关联。 编码不同亚 …

2010年1月4日 · The alpha-7 (ITGA7)/beta-1 (ITGB1; 135630) integrin is a specific cellular receptor for the basement membrane protein laminin-1 (see 150320), as well as for laminin-2 (see 156225) and -4. The alpha-7 subunit is expressed mainly in skeletal and cardiac muscle and may be involved in differentiation and migration processes during myogenesis ...