Isofurans are nonclassic eicosanoids formed nonenzymatically by free radical mediated peroxidation of arachidonic acid. The isofurans are similar to the isoprostanes and are formed under similar conditions, but contain a substituted tetrahydrofuran ring.

Isoflurane reduces pain sensitivity (analgesia) and relaxes muscles. Isoflurane likely binds to GABA, glutamate and glycine receptors, but has different effects on each receptor.

We recently reported the discovery of isofurans, novel products of free radical-induced peroxidation of arachidonic acid that exhibit favored formation with increasing oxygen concentrations. In this review, the biochemistry of isofuran formation is compared with that of isoprostanes, with an emphasi …

2016年11月1日 · Polyunsaturated fatty acids (PUFA) are oxidized in vivo under oxidative stress through free radical pathway and release cyclic oxygenated metabolites, which are commonly classified as isoprostanes and isofurans. The discovery of isoprostanes goes back twenty-five years compared to fifteen years for isofurans, and great many are discovered.

Isoprostanes are prostaglandin‐like compounds that are formed non‐enzymatically by free radical‐catalyzed peroxidation of arachidonic acid (C20:4ω6). Intermediates in the pathway of the formation of isoprostanes are labile prostaglandin H 2 ‐like bicyclic endoperoxides (H 2 …

F2-异前列腺素(F2-Isoprostane, F2-IsoP)和Isofuran(IsoF)均为体内脂质过氧化的特异性标志物，其水平在蛛网膜下腔出血(subarachnoid hemorrhage, SAH)后升高并具有预后意义。

Isofurans are nonclassic eicosanoids formed nonenzymatically by free radical mediated peroxidation of arachidonic acid. The isofurans are similar to the isoprostanes and are formed under similar conditions, but contain a substituted tetrahydrofuran ring.

Isoflurane is an organofluorine compound. It has a role as an inhalation anaesthetic. It is functionally related to a methoxyethane. A stable, non-explosive inhalation anesthetic, relatively free from significant side effects. Isoflurane is a General Anesthetic. The physiologic effect of isoflurane is by means of General Anesthesia. View More...

Oxidative stress stimulates the generation of a new class of lipid mediators called F2 -isoprostanes (F2 -IsoPs) and isofurans (IsoFs) that influence cellular behavior. This study investigated RBC-derived F2 -IsoPs and IsoFs during storage and their influence on human platelets (PLTs).

2004年1月1日 · There are eight different isofuran regioisomers, each of which can exist as 16 racemic diastereomers. Thus, 256 enantiomerically-pure isofurans can be formed. These molecules are of interest as measurement of isofurans provides a sensitive index of free-radical induced lipid peroxidation in vivo under conditions of elevated oxygen tension.