FPN signaling plays a crucial role in maintaining iron homeostasis through governing the level of intracellular iron. Serum iron storage is conversely related with the estrogen level in the female bodies, and women in post-menopause are possibly subjected to iron retention.

Clinical and experimental evidence suggest that estrogen manipulates intracellular iron metabolism and that elevated levels of estrogen associate with increased systemic iron availability. This has been attributed to the ability of estrogen to suppress hepcidin synthesis, maintain ferroportin integr …

Interaction of estrogen with iron at the systemic level is long suspected, but direct evidence linking the two is limited. In the present study, we examined the effects of 17β-estradiol (E2) on hepcidin, a key negative regulator of iron absorption from the liver.

2012年12月15日 · The association between iron status change and estrogen defect coupled to hepcidin upregulation suggests promising approaches to treat estrogen-related disorders, such as postmenopausal osteopenia and osteoporosis.

2012年7月1日 · This interaction largely consists of estrogen effects on menstrual blood flow, a major source of iron loss in premenopausal women (1, 2). However, in a recent publication in Endocrinology, the lab of Xi Huang describes a direct mechanism of interaction between estrogens and hepcidin, the peptide hormone that regulates iron transport and ...

2022年7月12日 · It has been found that estrogen could regulate iron metabolism in neurons and astrocytes in different ways. The role of estrogen on iron metabolism in microglia is currently unknown. In this study, we investigated the effect and mechanism of 17β-estrogen (E2) on iron transport proteins.

2015年5月1日 · This study provides additional explanation for body iron changes in women upon estrogen alterations, such as a dramatic decline in the estrogen level in postmenopausal women.

It has been found that estrogen could regulate iron metabolism in neurons and astrocytes in different ways. The role of estrogen on iron metabolism in microglia is currently unknown. In this study, we investigated the effect and mechanism of 17β-estrogen (E2) on iron transport proteins.

Clinical and experimental evidence suggest that estrogen manipulates intracellular iron metabolism and that elevated levels of estrogen associate with increased systemic iron availability.

The reproductive hormones estrogen and progesterone influence iron regulation and contribute to variations in iron parameters throughout the menstrual cycle. Despite the high prevalence of iron deficiency in premenopausal females, scant research has investigated female-specific causes and treatments for iron deficiency.