Mar 30, 2025 · IRAK3 (Interleukin 1 Receptor Associated Kinase 3) is a Protein Coding gene. Diseases associated with IRAK3 include Asthma-Related Traits 5 and Multisystem Inflammatory Syndrome In Children. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Toll Comparative Pathway.

Oct 29, 2019 · Interleukin-1 receptor associated kinase 3 (IRAK3) is a cytoplasmic homeostatic mediator of inflammatory responses and is potentially useful as a prognostic marker in inflammation. IRAK3...

Aug 22, 2016 · IRAK3 has a well-established role in regulating innate immune responsiveness, mediating immune tolerance, and is a potent negative regulator of TLR/IL1R signaling. This …

IRAK3 is a critical modulator of inflammation in innate immunity. IRAK3 is associated with many inflammatory diseases, including sepsis, and is required in endotoxin tolerance to maintain homeostasis of inflammation.

Feb 8, 2025 · IRAK3 modulates downstream innate immune signalling through its guanylate cyclase activity. Findings demonstrated a distinctive role of IRAK-M in maintaining chronic Th2 airway inflammation and indicated a complex role for IRAK-M in the initiation and progression of experimental allergic asthma.

Jun 25, 2024 · Researchers have shown that modulating IRAK3 activity can be beneficial in managing various inflammatory and immune-related disorders. This blog post delves into the world of IRAK3 inhibitors, shedding light on their mechanisms, functions, and …

Interleukin-1 receptor-associated kinase-3 (IRAK3) is a critical checkpoint molecule of inflammatory responses in the innate immune system. The pseudokinase domain of IRAK3 contains a guanylate cyclase (GC) centre that generates small amounts of ...

Oct 7, 2014 · Interleukin-1 receptor-associated kinase (IRAK) family members are mediators of TLR/IL1R superfamily signalling, and mounting evidence implicates these kinases as viable cancer targets.

Jan 4, 2025 · Gene target information for IRAK3 - interleukin 1 receptor associated kinase 3 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Mar 4, 2021 · The IRAK3 pseudokinase domain forms a head-to-head dimer, suggesting a new mode of kinase/pseudokinase allostery by which IRAK3 could attenuate the activity of IRAK4 in cells. Innate immune responses to pathogen exposure lead to engagement of inflammatory signaling pathways in macrophages.