白介素2受体γ链 （interleukin 2 receptor subunit gamma chain, IL2Rg，或CD132），是多种重要免疫因子的共同受体亚基，包括IL-2、IL-4、IL-7、IL-9、IL-15和IL-21，因此，也被称为受体共同γ链（common gamma chain，γc）。 IL2Rg是一种表达于大部分淋巴细胞表面的糖蛋白，在哺乳动物中，IL2Rg基因位于X染色体上。 图1. IL2Rg是多种重要免疫因子的共同受体亚基 [1] IL2Rg家族细胞因子. IL2Rg家族中的细胞因子（IL-2、IL-4、IL-7、IL-9、IL-15和IL-21）有着不同的生 …

The common gamma chain (γ c) (or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, [5] IL-7, [6] IL-9, IL-15 [7] and interleukin-21 receptor.

2025年3月30日 · IL2RG (Interleukin 2 Receptor Subunit Gamma) is a Protein Coding gene. Diseases associated with IL2RG include Severe Combined Immunodeficiency, X-Linked and Combined Immunodeficiency, X-Linked . Among its related pathways are IL-9 Signaling Pathways and Interleukin-2 family signaling .

IL-2受体是由α、β、γ三条链组成的异聚体，即IL-2R由 IL-2Rα （CD25）、 IL-2Rβ （CD122）、 IL-2Rγ （CD132）组成。 其中β/γ为下游信号通路激活所必需，α则主要促进二者结合。 当IL-2受体α亚基（IL-2RA）单独存在时，其与IL-2的亲和力只有完整的IL-2受体的百分之一，因此IL-2R分为高、中、低亲和力受体。 IL2RA在 Treg细胞 表达。 TCR或IL-2刺激T细胞后，IL2RA转录增强。 其它细胞因子也能诱导其转录，如 IL-7、IL-12、IL-15、TNF 和 TGF-β。 IL2RB和IL2RG在多 …

Data indicate a nonsense mutation in exon 8 (p.R328X) of interleukin (IL)-2 receptor common gamma chain gene (IL2RG)in two brothers were diagnosed with X-Linked combined Immunodeficiency (X-SCID). High IL2RG expression is associated with peripheral Tcell lymphoma expressing the ITKSYK fusion gene.

2025年2月8日 · Clinical resource with information about IL2RG, Combined immunodeficiency, X-linked, X-linked severe combined immunodeficiency, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

The IL2RG gene provides instructions for making a protein called the common gamma chain. This protein is a component of several different receptors that are involved in immune system function. The receptors span the cell membrane, with one end outside the cell like an antenna and the other end inside to transmit signals to the nucleus.

2016年5月19日 · The IL2RG gene encodes the γ c portion of the IL-2 receptor, which along with IL-2Rα and IL-2Rβ makes up the entire IL-2 receptor. The γ c portion interacts with the IL-2 cytokine, and it has fundamental function in the development of regulatory T cells, maintaining peripheral tolerance, as well as increasing the cytolytic activity of NK ...

由该基因编码的蛋白质是许多白细胞介素受体的重要信号成分，包括白细胞介素-2、-4、-7 和-21，因此被称为共同γ链。 该基因的突变会导致 X 连锁严重联合免疫缺陷 (XSCID) 以及 X 连锁联合免疫缺陷 (XCID) ，这是一种不太严重的免疫缺陷病。 [RefSeq 提供，2010 年 3 月]

2018年8月8日 · IL-2Rγ then interacts to form the high-affinity receptor 10, with signalling mediated by heterodimerization of the IL-2Rβ and IL-2Rγ cytoplasmic domains 11, 12. Interestingly, regulatory T (T reg)...