Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene. [5] The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21).

其中， 白介素IL21 （Interleukin 21）是主要的免疫调节剂之一，通过影响多种免疫细胞来调节各种免疫应答。 百奥动物开发了 B-hIL21R mice，为临床前药效评估提供了优质模型。 关于靶点IL21. IL21R编码白细胞介素21 (IL21)的细胞因子受体。 它属于I型细胞因子受体，并已被证明与 共同γ链 （γc）形成异二聚体受体复合物。 γc亚基也是IL2、IL4、IL7、IL9和IL15的共同受体。 该受体转导IL21的促生长信号，对T细胞、B细胞和自然杀伤 (NK)细胞的增殖和分化具有重要意义 …

2025年3月30日 · IL21R (Interleukin 21 Receptor) is a Protein Coding gene. Diseases associated with IL21R include Immunodeficiency 56 and Cryptosporidiosis-Chronic Cholangitis-Liver Disease Syndrome. Among its related pathways are Cytokine Signaling in …

白介素-21受体（英語： Interleukin-21 receptor ，缩写IL21R）也称为分化簇360（CD360，cluster of differentiation 360）是一种细胞表面蛋白质，由人类基因 IL21R 编码 [6] ，能与白细胞介素-21（IL-21）结合。

Its private receptor, IL-21R, has been shown to activate the Janus kinase/signal transducers and activators of transcription signaling pathway upon ligand binding. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, natural killer, and dendritic cells.

2014年4月22日 · Interleukin-21 (IL-21) binding stabilizes the complex between the IL-21 receptor (IL-21R) and the common cytokine-γ chain, γ c, leading to the activation of Janus kinase 1...

Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens. Chromosomal aberrations involving IL21R is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t (3;16) (q27;p11), with BCL6.

2025年2月8日 · IL21R hypomethylation as a biomarker for distinguishing benign and malignant breast tumours. Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA[+] B cells.

该基因编码的蛋白质是白细胞介素 21 (IL21) 的细胞因子受体。 它属于 I 型细胞因子受体，已被证明与共同的 γ 链形成异二聚体受体复合物，γ 链是白细胞介素 2、4、7、9 和 15 的受体也共享的受体亚基。 该受体转导 IL21 的生长促进信号，对 T 细胞、B 细胞和自然杀伤 (NK) 细胞的增殖和分化很重要。 该受体的配体结合导致多个下游信号分子的激活，包括 JAK1、JAK3、STAT1 和 STAT3。 对小鼠中相似基因的敲除研究表明该基因在调节免疫球蛋白产生中的作用。 已经描 …

2024年12月9日 · The IL21/IL21R axis reduced the growth and invasion of NSCLC cells via inhibiting Wnt/betacatenin signaling and PDL1 expression. The present results may provide a novel molecular target for NSCLC diagnosis and therapy.