Interleukin 27 (IL-27) is a member of the IL-12 cytokine family. It is a heterodimeric cytokine that is encoded by two distinct genes, Epstein-Barr virus-induced gene 3 (EBI3) and IL-27p28. IL-27 …

2025年2月5日 · Here we show that expression of a CTL signature is strongly associated with IL27 expression in human and mouse tumours. In mice, IL-27 acts directly on tumour-specific CTLs …

Interleukin-27 (IL27) is a recently discovered cytokine belonging to the IL6/IL12 cytokine family [1]. Due to the heterodimeric nature of these cytokines and their receptors, studies on the IL12 …

2021年11月24日 · Here we define a critical role of IL-27–IL-27Rα signalling in improving thermogenesis, protecting against diet-induced obesity and ameliorating insulin resistance. …

IL-27 is a pleiotropic cytokine that has diverse immune regulatory activities under both physiological and pathological conditions. IL-27 enhances the functions of Th1 and CD8 + T …

Our data demonstrate that endogenous IL-27 is essential for anti-tumour immunity and that IL-27 receptor agonism can safely improve anti-tumour T cell responses alone or in combination …

Interleukin-27 (IL-27), a member of the IL-6/IL-12 family, has diverse regulatory functions in various immune responses, and is recognised as a potent agonist and antagonist of CD4+T …

2012年12月12日 · Interleukin-27 (IL-27) is a heterodimeric cytokine composed of the Epstein-Barr virus-induced gene 3 (EBi3) and IL-27p28, which engages a receptor composed of gp130 and …

Interleukin (IL)-27, a member of the IL-6/IL-12 family, has an important role in modulating inflammation in partnership with innate and adaptive immune cells. IL-27 binding to IL-27R …

Interleukin-27 (IL-27) is a new member of the IL-12 family. It is produced by activated antigen-presenting cells and plays an important role in the regulation of CD4+ T cell differentiation and …