Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene. [4][5] Interferon regulatory factor 1 was the first member of the interferon regulatory transcription …

2024年12月25日 · IRF1 (Interferon Regulatory Factor 1) is a Protein Coding gene. Diseases associated with IRF1 include Immunodeficiency 117 and Gastric Cancer. Among its related …

2021年1月21日 · Given the diverse array of effectors that exist in the IRF1 regulome, understanding the mechanisms underlying the protective role of IRF1 can be expected to …

Innate immune signaling can induce the expression of interferon (IFN) regulatory factor 1 (IRF1), an important molecule in innate immune activation and cell death. While IRF1 has been shown …

irf1是最早发现的具备调节 干扰素 转录表达调控功能的高效调节因子。多年来并未完全揭示其在抗病毒天然免疫信号通路中的生物学功能。 多年来并未完全揭示其在抗病毒天然免疫信号通路 …

编码的蛋白质激活参与机体对病毒和细菌反应的基因的转录，在细胞增殖、细胞凋亡、免疫反应和 DNA 损伤反应中发挥作用。 这种蛋白质抑制其他几个基因的转录。 作为肿瘤抑制因子，它既 …

2021年1月21日 · The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I …

IRF1 re-expression in human cancer cells causes cells to become resistant to infection by the oncolytic vesicular stomatitis virus strain. IRF1 is a dual regulator of BV6-induced apoptosis …

IRF1 编码干扰素调节因子1蛋白（IRF1），作者在HEK293T细胞中 瞬时转染 p.R129*和p.Q35*，发现这两个突变体丧失了转录活性，无法产生IRF1。 RT-qPCR显示P1和P2 …

2006年9月1日 · Four IRFs — IRF1, IRF3, IRF5 and IRF7 — have been implicated as positive regulators of the transcription of type I IFN genes 4,14. IRF1 was the first IRF-family member …