IRF-1 (D5E4) XP® Rabbit mAb | Cell Signaling Technology
3 天之前 · IRF-1 (D5E4) XP ® Rabbit mAb recognizes endogenous levels of total IRF-1 protein. Human, Mouse, Rat. Monoclonal antibody is produced by immunizing animals with a synthetic …
Interferon regulatory factor 1 (IRF1) and anti-pathogen innate
2021年1月21日 · In 1988, IFN-regulatory factor 1 (IRF1), the first member of the IRF family to be recognized, was identified by the Taniguchi laboratory in crude nuclear extracts of Newcastle …
IRF1 - Wikipedia
IRF-1 regulates expression of target genes by binding to an interferon stimulated response element (ISRE) in their promoters. The IRF-1 protein binds to the ISRE via an N-terminal helix …
Interferon Regulatory Factor-1 (IRF-1) Shapes Both Innate and CD8
2011年9月1日 · Interferon regulatory factor (IRF)-1 is an immunomodulatory transcription factor that functions downstream of pathogen recognition receptor signaling and has been implicated …
IRF1 regulates self-renewal and stress responsiveness to ... - Science
2023年10月27日 · We investigated the role of interferon regulatory factor 1 (IRF1), a transcription factor that is affected by multiple inflammatory stimuli, in HSC regulation. Our findings …
IRF1 governs the differential interferon-stimulated gene responses …
2021年3月23日 · We found that TLR4 activation in MDMs enables chromatin opening at ISG loci. Finally, we identified an essential role for IRF1 in regulating chromatin accessibility and …
Identification of IRF1 as critical dual regulator of Smac mimetic ...
2014年12月11日 · Here, we identify interferon regulatory factor 1 (IRF1) as a novel critical regulator of Smac mimetic BV6-induced apoptosis and proinflammatory cytokine secretion …
Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria
2023年2月2日 · IRF1 encodes interferon regulatory factor 1 protein (IRF1), a transcription factor induced by IFN-γ, the deficiency of which in mice underlies susceptibility to various pathogens, …
IRF1 is a core transcriptional regulatory circuitry member …
2025年3月1日 · Interferon regulatory factor 1 (IRF1) ... activity of IRF1 (Fig. 5B), leading us to conclude that the E1 element was indeed the main active unit within IRF-SE. To further …
IRF1 cooperates with ISGF3 or GAF to form innate immune de …
2025年1月7日 · Together, our results reveal how combinatorial logic gates of IRF1-ISGF3 or IRF1-GAF restrict immune epigenomic memory formation to macrophages exposed to …
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