2025年2月8日 · This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease.

2022年12月14日 · IRAK4 Degrader (KT-474) Part C of Kymera’s KT-474 Phase 1 clinical trial was designed to confirm that the PK/PD and safety data previously demonstrated in healthy volunteers would translate into patients with hidradenitis suppurativa (HS) and atopic dermatitis (AD). Data was also collected on the change in circulating inflammatory biomarkers ...

2019年6月13日 · Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in Toll-like receptor (TLR) signal transduction and innate immune responses.

2024年12月25日 · IRAK4 (Interleukin 1 Receptor Associated Kinase 4) is a Protein Coding gene. Diseases associated with IRAK4 include Immunodeficiency 67 and Immunodeficiency 33. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and …

2024年12月1日 · Interleukin-1 receptor-related kinase (IRAK4) is a widely expressed serine/threonine kinase involved in the regulation of innate immunity. IRAK4 plays a pivotal role as a key kinase within the downstream signaling pathway cascades of interleukin-1 receptors (IL-1R) and Toll-like receptors (TLRs).

Mutually exclusive expression of a hypermorphic long IRAK4 (IRAK4-L) isoform over a hypomorphic short (IRAK4-S) isoform predicts clinical aggressiveness and worse outcomes in AML patients . Treatment with an IRAK4 inhibitor potently suppresses leukemic function in AML cell lines with predominant IRAK4-L expression [ 65 ].

2025年2月17日 · The IL-1R/TLRs signaling pathway holds a pivotal position within the innate immune system, highlighting its importance in various pathological processes. IRAK4, as the key kinase in this intricate signaling cascade, emerges as a …

2023年10月5日 · IRAK-4 is a key signal transduction node in the regulation of IL-1R and TLRs pathways. Targeting IRAK-4 is a promising method for inflammation, auto-immune diseases and cancers. This review focuses on the mechanism, clinical application and structural optimization of IRAK-4 inhibitors and degraders.

Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) is a key mediator of innate immunity. IRAK4 overactivation is linked with several autoimmune diseases. To date, many IRAK4 inhibitors have been developed to block the protein’s kinase activity with ...

2025年1月6日 · Interleukin-1 receptor-associated kinase 4 (IRAK4) is involved in various inflammation-related diseases. Both the kinase and scaffolding functions of IRAK4 initiate pro-inflammatory factor transcription and expression. The scaffolding function of IRAK4 is essential for Myddosome assembly and NF-κB activation.