Interleukin-1 receptor-associated kinase 1 (IRAK-1) is an enzyme in humans encoded by the IRAK1 gene. [5] [6] IRAK-1 plays an important role in the regulation of the expression of inflammatory genes by immune cells, such as monocytes and macrophages, which in turn help the immune system in eliminating bacteria, viruses, and other pathogens.

Interleukin-1 receptor activated kinases (IRAKs) are key mediators in the signaling pathways of TLRs/IL-1Rs. By means of their kinase and adaptor functions, IRAKs initiate a cascade of signaling events eventually leading to induction of inflammatory target gene expression.

一类与IL-1R和TLR信号转导相关的丝氨酸-苏氨酸蛋白激酶，已发现IRAK-1、IRAK-2、IRAK-M和IRAK-4，均含死亡结构域 (DD)。 IRAK1、IRAK2表达广泛，IRAK-M仅表达于单核细胞来源的细胞。 磷酸化IRAK-1可与TRAF6结合，激活NF-κB。 一类与IL-1R和TLR信号转导相关的丝氨酸-苏氨酸蛋白激酶，已发现IRAK-1、IRAK-2、IRAK-M和IRAK-4，均含死亡结构域 (DD)。 IRAK1、IRAK2表达广泛，IRAK-M仅表达于单核细胞来源的细胞。 磷酸化IRAK-1可与TRAF6结合，激 …

Interleukin receptor-associated kinase (IRAK) proteins are pivotal in interleukin-1 and Toll-like receptor-mediated signaling pathways. They play essential roles in innate immunity and inflammation. This review analyzes and discusses the physiological functions of IRAK1 and its associated diseases.

2024年12月25日 · IRAK1 (Interleukin 1 Receptor Associated Kinase 1) is a Protein Coding gene. Diseases associated with IRAK1 include Pediatric Systemic Lupus Erythematosus and Mumps. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Bacterial infections in …

IRAK1 is a threonine/serine kinase. Unlike IRAK4, IRAK1 is not a core constituent of the Myddosome but transiently interacts with IRAK4 upon Myddosome assembly. Unlike IRAK4, IRAK1 exists primarily in an inactive conformation at the basal state and requires upstream stimulation for rapid activation .

该基因编码白细胞介素 1 受体相关激酶 1，这是两种推定的丝氨酸/苏氨酸激酶之一，在刺激后与白细胞介素 1 受体 (IL1R) 相关。 该基因部分负责 IL1 诱导的转录因子 NF-kappa B 的上调。 已 …

Signaling via most TLRs and IL-1Rs is mediated by the protein myeloid differentiation primary-response protein 88 (MyD88). This signaling adaptor forms the scaffold of the myddosome, a molecular platform that employs IL-1R-associated kinase (IRAK) proteins as main players for transducing signals.

2022年1月1日 · The interleukin 1 receptor-associated kinases (IRAKs) are a family of related signaling intermediates (IRAK1, IRAK2, IRAK3, IRAK4) that operate at the nexus of multiple inflammatory pathways implicated in the hematologic malignancies.

2008年2月1日 · Interleukin-1 receptor activated kinases (IRAKs) are key mediators in the signaling pathways of TLRs/IL-1Rs. By means of their kinase and adaptor functions, IRAKs initiate a cascade of signaling events eventually leading to …