Interleukin 6 (IL-6) is a pleiotropic cytokine with a pivotal role in the pathophysiology of rheumatoid arthritis (RA). It is found in abundance in the synovial fluid and serum of patients with RA and …

In this paper, we present current evidence of the pathological role of IL-6 in the development of RA and the efficacy and safety profile of TCZ for RA and discuss future aspects of IL-6 …

An increase in serum IL-6 and IL-21 levels is associated with markers of B cell activation, and IL-6 is associated with radiographic progression in patients with RA . Based on studies …

2020年7月23日 · The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory …

2020年10月20日 · Increased levels of cytokines, including interleukin-6 (IL-6), reflect inflammation and have been shown to be predictive of therapeutic responses, fatigue, pain, and depression …

Rheumatoid arthritis (RA) is an autoimmune chronic disease with joint and systemic inflammation and it has been found that interleukin-6 (IL-6) plays a key role in RA. Indeed, various clinical …

2024年12月15日 · at present, there are inconsistent research findings regarding the precise relationship between IL-6 gene polymorphisms (GPMs) and rheumatoid arthritis (RA). This …

2022年1月1日 · IL-6 is involved in pathogenesis of rheumatoid arthritis (RA) and its comorbidities. IL-6 inhibition is associated with improvements of many RA comorbidities. Interleukin (IL)-6 is …

2020年7月30日 · This narrative review describes the role of IL-6 in the pathogenesis of RA, its comorbidities, and extra-articular systemic manifestations, and examines the effects of the IL-6 …

Inhibitors of IL-6 action can target either the IL-6 ligand itself or the IL-6 receptor. Tocilizumab is a humanized monoclonal antibody targeting the IL-6 receptor that was approved by the FDA in …