2021年1月11日 · This study reveals a double-edged role for IL-2 in regulating tumor-specific CD8 + T cells. IL-2 can promote CD8 + T cell activation and proliferation at an early tumor stage, but can...

2024年7月1日 · We explored the theory that targeting of IL2 to CD8+ T cells, which are key antitumor effectors, could enhance its therapeutic index. To this aim, we developed AB248, a CD8 cis-targeted IL2 that demonstrates over 500-fold preference for CD8+ T cells over natural killer and regulatory T cells (Tregs), which may contribute to toxicity and ...

2022年2月11日 · IL-2 is known to play multiple roles during the generation of effector and memory CD8 T cell responses. Here, Kahan et al. show that a subset of CD8 T cells with the capacity to intrinsically express IL-2 has stem-like features, displays a memory phenotype, can resist exhaustion, and controls chronic viral infection.

We find that a continuously high level of IL-2 leads to the persistent activation of STAT5 in CD8 + T cells, which in turn induces strong expression of tryptophan hydroxylase 1, thus catalyzing the conversion to tryptophan to 5-hydroxytryptophan (5-HTP). 5-HTP subsequently activates AhR nuclear translocation, causing a coordinated upregulation ...

2021年1月14日 · 2021 年 1 月 11 日，中国医学科学院北京协和医学院黄波教授团队在 Nature Immunology 杂志在线发表了题为：IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor 的研究论文【2】。 这项研究发现肿瘤微环境中的 IL-2 可诱导 CD8+ T 细胞耗竭，进而抑制抗肿瘤免疫反应！ 起初，作者希望研究缺乏 IL-2 信号是否会导致肿瘤浸润性 T 细胞进入耗竭状态。 但是令人意外的是，TCGA 数据库分析发现，IL-2 表达 …

2024年9月11日 · Here authors show that MRTF/SRF inactivation leads to decreased IL-2 mediated CD8 + T cell proliferation during infection, resulting from disrupted homotypic cell clustering and reduced...

2021年9月15日 · Here we show that H9T, an engineered interleukin-2 partial agonist, promotes the expansion of CD8 + T cells without driving terminal differentiation. H9T led to altered STAT5 signalling and...

2024年3月12日 · The balance between short-lived Teff and memory precursors is regulated by duration of antigen exposure and inflammatory cytokines as well as the concentration and timing of IL-2 (Figure 4B). CD8 + Teff cells with high amounts of CD25 during the primary response exhibit robust proliferation and develop high effector function, yet are more prone ...

2023年10月10日 · Strong IL-2 receptor stimulation of antigen-activated CD8 + T cells induces a unique gene expression program in which the cells harbor a superior cytotoxicity and anticancer/antiviral potential. This effect can be achieved by exogenous IL-2-based therapy or depletion of Tregs.

4 天之前 · 近日，我室院周德敏、纪德重团队在 Advanced Science 发表最新成果，他们通过设计具有协同效应的受体偏向性 IL-2 变体组合，实现了对调节性 T 细胞（ Treg ）和 CD8+ T 细胞命运的精准调控，在动物模型中展现出显著的抗肿瘤效果，为开发基于 IL-2 的癌症免疫治疗策略提供了 …