The cytokine interleukin-1β (IL-1β) is a key mediator of the inflammatory response. Essential for the host-response and resistance to pathogens, it also exacerbates damage during chronic disease and acute tissue injury.

IL-1β is the most studied member of the IL-1 family due to its role in mediating autoinflammatory diseases. 4 Unquestionably, IL-1β evolved to assist host defense against infection 5 and this landmark study established how a low dose of recombinant IL-1β protects mice against lethal bacterial infection in the absence of neutrophils.

IL-1β is a pro-inflammatory cytokine that has been implicated in pain, inflammation and autoimmune conditions. This review will focus on studies that shed light on the critical role of IL-1β in various pain states, including the role of the intracellular complex, the inflammasome, which regulates IL-1β production.

2025年3月30日 · IL1B (Interleukin 1 Beta) is a Protein Coding gene. Diseases associated with IL1B include Gastric Cancer and Diffuse Gastric And Lobular Breast Cancer Syndrome. Among its related pathways are MIF Mediated Glucocorticoid Regulation and …

Interleukin-1 (IL-1) is a cytokine which governs inflammatory responses by binding IL-1 α and β agonist with its receptor IL-1R (Vigers et al., 1997). IL-1β is synthesized by inflamasome-mediated caspase action (Bent et al., 2018) and enhances the immune reaction (Dinarello, 2014).

2025年3月26日 · Interleukin-1beta moderates the relationships between middle frontal-mACC/insular connectivity and depressive symptoms in bipolar II depression. Intense impact of IL-1beta expressing inflammatory macrophages in acute aortic dissection.

This pathway summarizes extracellular and intracellular signaling of IL-1α or IL-1β, including positive- and negative-feedback mechanisms that amplify or terminate the IL-1 response.

2019年6月6日 · Interleukin-1 receptors and inhibitors of IL-1 signaling. a IL-1R1 interacts with both IL-1α and IL-1β and promotes signal transduction, together with its co-receptor IL-1R3 (IL-1RAcP).

IL1B is a gene that encodes the proinflammatory cytokine IL-1β, which plays a crucial role in the central nervous system by inducing various behavioral changes and responses to stress. You might find these chapters and articles relevant to this topic. Wenyuan Yin, ... John F. Sheridan.

2010年1月19日 · Once activated, it orchestrates the inflammatory response by secreting proinflammatory cytokines, such as interleukin-1 (IL-1)–type cytokines, in particular IL-1β. IL-1 …