The I region of the mouse H-2 gene complex codes for four Ia genes, Aα, Aβ, Eβ and Eα, whose gene products express the Ia determinants. Aα, Aβ and Eβ map within the I-A subregion, while Eα maps to the I-E subregion.

Interspecies cross-reactions of anti-Ia mouse alloantibodies have indeed been observed. Although such a cross-reaction was first found between mouse I–A and rat Ia-homologues, subsequent...

1986年1月1日 · Expression of the murine Ia antigens is highly regulated, normally being limited to only a few cell types. Much of the regulation takes place at the level of mRNA synthesis; how is the transcription of Ia genes controlled?

The contributions of different allelically variable regions of Ia molecules to both of these processes were analyzed by transfection of L cells with various A beta and A alpha gene pairs. The results show that, with regard to quantitative and qualitative aspects of Ia expression, the polymorphisms in the A beta chain segregate into two groups.

The human gene encoding the Ia-associated gamma (or invariant) chain was isolated by screening a genomic library in phage lambda with cDNA probes. The frequency of positive clones in the library, the overlapping restriction maps of the cloned fragments, and the patterns of genomic hybridization suggested that the gamma-chain gene exists as a ...

The Ia antigens constitute a polymorphic series of cell surface determinants. At present, their definition is mainly a genetic one, and thus any cell surface antigen which can be demonstrated to be encoded by a gene in the Ir region of the H-2 complex may be classified as an Ia antigen.

The class II genes code for the classical ‘Ia antigens’ which consists of two polypeptide chains of 31,000 and 28,000 daltons in a non-covalent association and expressed predominantly on lymphoid cells. These molecules are involved in the presentation of non-self antigens and activation of the T-helper cell.

Ia alloantigens are surface glycoproteins found on lymphocytes and macrophages and probably some other cell types (Shreffler and David, 1975; Hammerling et al., 1975; Cowing et al., 1978). They are antigenically quite variable, and their structure is encoded in genes...

2004年5月12日 · Phospholipase A 2 (PLA 2) genes expressed in the venom glands of the sea snake, Laticauda semifasciata, were investigated. Both mRNAs, encoding group IA (without a pancreatic loop) and group IB (with pancreatic loop), were detected from venom glands by Northern blot hybridization analysis and RT-PCR.

Gene rearrangement of adaptive immune antigen recognition receptors proceeds in individual lymphocytes (Eason et al., 2004; Imkeller & Wardemann, 2018; Yanagi et al., 1985). The number of different antigen receptors is staggering, measured in billions, whereas the number of innate immune response antigen recognition receptors is much fewer.