Hypericin is a naphthodianthrone, an anthraquinone derivative which, together with hyperforin, is one of the principal active constituents of Hypericum (Saint John's wort). [2] [3] Hypericin is believed to act as an antibiotic, antiviral [2] and non-specific kinase inhibitor.Hypericin may inhibit the action of the enzyme dopamine β-hydroxylase, leading to increased dopamine levels, …

Hypericin is a naturally occurring substance found in the common St. John's Wort (Hypericum species) and can also be synthesized from the anthraquinone derivative emodin. As the main component of Hypericum perforatum, it has traditionally been used throughout the history of folk medicine. In the last three decades, hypericin has also become the ...

2024年1月12日 · St. John's wort is a herb containing hypericin, which seems to give it antibacterial and antiviral properties. Many people use St. John's wort to help treat depression, anxiety, and ADHD. It has ...

Hypericin is an anthraquinone derivative that is naturally extracted from Hypericum perforatum a yellow flowering herb generally known as St. John’s Wort. Hypericin-mediated PDT has been used for the treatment of different type of cancer including skin (Table 3) [104], cervical [105, 106], glioma [107], and bladder [108] tumors. It is known ...

Abstract. Hypericin (4,5,7,4′,5′,7′-hexahydroxy-2,2′-dimethylnaphtodianthrone) is a naturally occurring chromophore found in some species of the genus Hypericum, especially Hypericum perforatum L. (St. John's wort), and in some basidiomycetes (Dermocybe spp.) or endophytic fungi (Thielavia subthermophila).In recent decades, hypericin has been intensively studied for …

Hypericin is under investigation for the treatment of Cutaneous T-cell Lymphoma. DrugBank Hypericin has been reported in Hypericum ascyron , Hypericum tomentosum , and other organisms with data available.

2023年3月1日 · Hypericin can be mainly obtained by the extraction from plant and synthesis (biosynthesis and chemical synthesis), which means the further studies shall be conducted on plant distribution, biosynthesis and chemical synthesis. On the other hand, the poor solubility of hypericin greatly limits its pharmacological effects.

Hypericin has been extensively studied for its physicochemical properties, little is known however, for pseudohypericin. Hypericin is not planar, as indicated by X-ray diffraction studies . The side chains of the aromatic skeletons repel each other and prevent the molecule from acquiring a planar conformation.

2023年9月10日 · Hypericin can be derived from St. John's wort, which is widely spread around the world. As a natural product, it has been put into clinical practice such as wound healing and depression for a long time. In this article, we review the pharmacology, pharmacokinetics, and safety of hypericin, aiming to …

Introduction to Hypericin: A Natural Photosensitizer. Hypericin is a naturally occurring compound found in the herb St. John’s Wort (Hypericum perforatum) and is known for its potent photodynamic properties. It belongs to a class of compounds called photosensitizers, which means it can absorb light and transfer energy to other molecules.