2023年9月13日 · Human NLRP1 (NLRP1) is a multi-domain protein that comprises an N-terminal pyrin domain (PYD), a disordered linker region, a central NOD, a leucine-rich repeat (LRR) domain, a function to find...

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2021年4月29日 · Structure-guided biochemical and functional assays show that both NLRP1 binding and enzymatic activity are required for DPP9 to suppress NLRP1 in human cells. Together, our data reveal the...

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2019年10月17日 · Two pathways have been found to trigger pyroptosis: caspase‐1 mediated inflammasome pathway with the involvement of NLRP1‐, NLRP3‐, NLRC4‐, AIM2‐, pyrin‐inflammasome (canonical inflammasome...

NLRP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. It interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment. domain, and is a member of the XhoI PspXI NALP3 inflammasome complex.

2023年1月17日 · Here, together with a companion study, we report that the NLRP1 inflammasome detects Exotoxin A (EXOA), a ribotoxin released by P. aeruginosa Type 2 Secretion System (T2SS) during chronic infection.

2021年11月15日 · In this present investigation, a new α-Tetralone based chalcone compound, (2E)-2- (4-ethoxybenzylidene)-3,4-dihydro-2H-naphthalen-1-one (EBDN) has been synthesized and grown through a slow evaporation solution growth technique. The molecular structure of grown EBDN has been characterized by SCXRD, FT-IR, …

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2025年1月22日 · 48K likes, 313 comments - fcbarcelona on January 22, 2025: "Flick mentality 易".