Hirudin is the most potent natural inhibitor of thrombin. Unlike antithrombin, hirudin binds to and inhibits only the activated thrombin, with a specific activity on fibrinogen. [8] .

Hirudin, an acidic polypeptide secreted by the salivary glands of Hirudo medicinalis (also known as “Shuizhi” in traditional Chinese medicine), is the strongest natural specific inhibitor of …

Hirudin is a single-chain 65-amino acid polypeptide (7,000 Da) that forms an irreversible 1:1 complex with thrombin. Hirudin interacts with both the fibrinogen-binding and catalytic sites of …

The anticoagulant hirudin, which is extracted from the body tissues of the European medicinal leech (Hirudo medicinalis), is used to prevent blood clots following surgery; another chemical …

Hirudin is the most potent and specific known inhibitor of thrombin, the enzyme that plays a key regulatory function in hemostasis and blood coagulation.

Over a century has passed since the anticoagulant properties of hirudin were identified. Our understanding of this unique and promising 65 amino acid polypeptide has grown steadily, …

2001年3月13日 · Hirudin was used for the first parenteral anticoagulation in humans in 1909 1 and as the anticoagulant for the first hemodialysis in humans. 2 Soon after, heparin became …

Natural hirudin is an active ingredient extracted from Hirudo medicinalis, which has been found to be the strongest natural specific inhibitor of thrombin. Evidence based on pharmacological …

2021年4月15日 · Hirudin, an acidic polypeptide secreted by the salivary glands of Hirudo medicinalis (also known as “Shuizhi” in traditional Chinese medicine), is the strongest natural …

Hirudin forms a biomolecular complex with thrombin via its acidic C-terminus and thereby prevents the activity of thrombin. Hirudin has been produced synthetically and used in the …