Hepcidin deficiency is the cause of iron overload in hereditary hemochromatosis, iron-loading anemias, and hepatitis C. Hepcidin excess is associated with anemia of inflammation, chronic …

Hepcidin is sometimes called the “master iron regulator” because it controls how much iron is available for your cells to perform essential processes, like making hemoglobin and red blood …

2025年2月1日 · Hepcidin, a key regulator of iron metabolism, plays a pivotal role in preventing iron release into the plasma from absorptive enterocytes and macrophages. Elucidating the …

2016年6月9日 · Hepcidin, a liver-derived peptide hormone, is a key regulator of systemic iron homeostasis, and its unbalanced production contributes to the pathogenesis of a spectrum of …

2012年9月1日 · Hepatic peptide hepcidin regulates iron absorption, plasma concentration and tissue distribution. It binds to its receptor/iron exporter ferroportin and causes its internalization …

2024年12月1日 · In mammals, hepcidin has two main functions including the regulation of iron homeostasis and as innate antimicrobial agent. Hepcidin controls iron export from absorptive …

2025年3月27日 · ERFE controls iron metabolism by suppressing the hepatic expression of the iron-regulator hormone hepcidin, mediated by interference with the action of the bone …

2003年8月1日 · Human hepcidin, a 25–amino acid peptide made by hepatocytes, may be a new mediator of innate immunity and the long-sought iron-regulatory hormone. The synthesis of …

2004年12月17日 · Hepcidin is a peptide hormone secreted by the liver in response to iron loading and inflammation. Decreased hepcidin leads to tissue iron overload, whereas hepcidin …

2015年5月14日 · Hepatic hormone hepcidin is a principal regulator of iron homeostasis and a pathogenic factor in common iron disorders. Hepcidin deficiency causes iron overload in …