Hepatocyte nuclear factor 4-alpha (HNF4α) is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs (pancreas, stomach, and intestine).

2021年1月18日 · Abnormal expression of HNF4α is emerging as a critical factor in cancer cell proliferation, apoptosis, invasion, dedifferentiation, and metastasis.

摘要: 肝细胞核因子 (HNF)4α属于细胞核受体超家族成员,在分化成熟的肝细胞中高表达。 HNF4α在转录水平上调控肝脏特异基因的表达,促进肝细胞的发育和分化,参与肝细胞极性的建立和维持,增强肝脏的合成、代谢以及解毒功能。 HNF4α可通过抑制肝星状细胞的活化、逆转上皮间质细胞转化、抑制肝癌细胞增殖、侵袭和转移等机制,参与肝纤维化、肝硬化、肝细胞癌等疾病的发生和变化过程。 阐述了HNF4α的生物学功能,对其参与多种主要肝脏疾病信号通路机制的研究进展进行了分 …

Hepatocyte nuclear factor 4 alpha (HNF4A) also known as NR2A1 (nuclear receptor subfamily 2, group A, member 1) is a nuclear receptor that in humans is encoded by the HNF4A gene. [5][6] HNF-4α is a nuclear transcription factor that binds DNA as a homodimer.

HNF4 (H epatocyte N uclear F actor 4) is a nuclear receptor protein mostly expressed in the liver, gut, kidney, and pancreatic beta cells that is critical for liver development. In humans, there are two paralogs of HNF4, HNF4α and HNF4γ, encoded by …

Hepatocyte Nuclear Factor 4alpha (HNF4alpha) Plays a Controlling Role in Expression of the Retinoic Acid Receptor beta (RARbeta) Gene in Hepatocytes. Hepatic nuclear factor 4 alpha promotes the ferroptosis of lung adenocarcinoma via transcriptional activation of cytochrome P450 oxidoreductase.

In this study, we investigated the effect of gain or loss of HNF4α function on the development and progression of NAFLD in mice. Approach and results: Overexpression of human HNF4α protected against high-fat/cholesterol/fructose (HFCF) diet-induced steatohepatitis, whereas loss of Hnf4α had opposite effects.

2015年3月3日 · The expression level of G9a is similar in HN12 and HN4 cells, but Snail expression is high in HN12 cells, and barely detectable in HN4 cells. This observation strongly supports the hypothesis that Snail level is the key factor for EMT induction.

甲基丙烯酸钾盐与氯乙醇在阻聚剂存在下反应生成粗甲基丙烯酸-2-羟基乙酯，经盐析、精制得成品。 本品主要用于树脂及涂料的改性。 与其他丙烯酸类单体共聚，所得树脂可含有活性羟基。 与三聚氰胺一甲醛（或脲醛）树脂、环氧树脂等共同反应，用于制造双组分涂料。 加入高级轿车油漆中，可长期保持镜面光泽。 还可用作合成纺织物的胶黏剂和医用高分子单体等。 本品毒性低，大鼠经口LD50为11.2 g/kg。 大鼠吸入试验器官正常，无中毒症状。 镀锌铁桶包装。 应在<10℃存 …

2. 相关产品 ：HN4所使用的饲养层细胞：CF-1 MEF 本细胞库可提供： SCSP-105 P0,可以增殖 SCSP-105R 已经经过射线处理，不再增殖，可直接作为feeder使用。 详情访问中科院干细胞库/干细胞技术平台http://www.cellbank.com.cn/index.asp； 电话：021-54921358 感谢您选择我们的服 …