TLR4 Signaling by Heme and the Role of Heme-Binding Blood …
TLR4 activation depends on the serum protein lipopolysaccharide (LPS)-binding protein, the co-receptor CD14 and myeloid differentiation protein-2 (MD-2) for bacterial recognition. Free …
Characterization of Heme as Activator of Toll-like Receptor 4
2007年7月13日 · Heme induces ROS generation, neutrophil recruitment and HO-1 expression independently of TLR4. A, peritoneal macrophages from Tlr4 +/+ (C3H/HePas) or Tlr4 d/d …
Heme triggers TLR4 signaling leading to endothelial cell activation …
2014年1月16日 · Heme/TLR4 signaling activates NF-κB and triggers vaso-occlusion through Weibel-Palade body degranulation and adhesion molecule expression. Treatment of sickle cell …
Insights into the molecular basis and mechanism of heme‐triggered TLR4 …
2023年10月26日 · We report the interaction of TLR4, MD2 and the TLR4-MD2 complex with heme and the consequences thereof by employing biochemical, spectroscopic, bioinformatic …
Heme triggers TLR4 signaling leading to endothelial cell
2014年1月16日 · TLR4 (-/-) mice transplanted with TLR4 (+/+) sickle bone marrow exhibited no heme-induced vaso-occlusion. The TLR4 agonist lipopolysaccharide (LPS) activated ECs and …
Insights into the molecular basis and mechanism of heme-triggered TLR4 …
We report the interaction of TLR4, MD2 and the TLR4-MD2 complex with heme and the consequences thereof by employing biochemical, spectroscopic, bioinformatic and …
Hemin and a metabolic derivative coprohemin modulate the TLR4 …
Recently, it has been suggested that activation of Toll-like receptor 4 (TLR4) is one of the ways in which the “danger signal” of free heme is detected. Here we examine the biochemical basis of …
Role of TLR4 signaling in the nephrotoxicity of heme and heme …
2018年5月1日 · Heme is now recognized as an agonist for the Toll-like receptor-4 (TLR4) receptor. This study examined whether the TLR4 receptor mediates the nephrotoxicity of …
TLR4 Signaling by Heme and the Role of Heme-Binding Blood …
2020年8月26日 · TLR4 activation depends on the serum protein lipopolysaccharide (LPS)-binding protein, the co-receptor CD14 and myeloid differentiation protein-2 (MD-2) for bacterial …
TLR4 activation alters labile heme levels to regulate BACH1 and …
2019年6月1日 · In the current study we hypothesized that alterations in the levels of intracellular labile heme in macrophages stimulated by lipopolysaccharide (LPS), a prototypical pro …