2023年3月21日 · H3K27me3 is reported to rarely be lost in a subset of other tumors, such as meningioma, radiation associated unclassified sarcoma, radiation associated angiosarcoma, undifferentiated pleomorphic sarcoma, osteosarcoma, dedifferentiated chondrosarcoma, melanoma and Merkel cell carcinoma (Pathol Res Pract 2018;214:417, Mod Pathol 2016;29:4 ...

2022年4月14日 · H3K27me3: H3 K27-altered tumors show loss of H3K27me3 staining, a finding that by itself is not specific, however, may be helpful in identifying diffuse midline gliomas with H3 p.K28I (K27I) mutation or EZHIP overexpression, which are negative for H3K27M IHC but show loss of nuclear H3K27me3 expression Reference: Brain Pathol 2016;26:569

2023年10月31日 · Loss of H3K27 trimethylation (H3K27me3) by IHC predicts poor prognosis in grade 1 and 2 meningiomas but not grade 3 (Acta Neuropathol 2018;135:955) TERT promoter mutation is seen in high grade meningioma progressed from low grade, not in primary atypical meningioma (Brain Pathol 2014;24:184)

2021年9月13日 · Also can have loss of H3K27me3 in 34% of cases (Mod Pathol 2016;29:582) Cellular schwannoma: Dilated vessels with hyalinized walls S100 and SOX10 are diffusely positive, TLE1+ in most cases, which can cause confusion Solitary fibrous tumor: CD34+ with a characteristic patternless pattern STAT6+ TLE1 can be positive in up to 40%

2020年11月5日 · Loss of H3K27me3 expression has good sensitivity and robust specificity for the diagnosis of MPNST; however, H3K27me3 expression is retained in epithelioid MPNST (Am J Surg Pathol 2016;40:479, Histopathology 2017;70:385)

Soft tissue stains: AE1 / AE3 ALK1 BCOR beta catenin caldesmon CAMTA1 CCNB3 (pending) CD31 CD34 CD99 CDK4 D2-40 DDIT3 (pending) desmin DOG1 DUX4 EBER EMA ERG ETV4 (pending) factor XIIIa FLI1 FOSB (pending) GLUT1 H3K27me3 HHV8 / LANA1 HMB45 c-kit / CD117 MDM2 MelanA MUC4 MYOD1 myogenin NKX2.2 (pending) NKX3.1 NR4A3 (pending) NSM1 (pending) pan ...

2024年4月4日 · H3K27me3. The H3K27 trimethylation status distinguishes PFA from PFB. PFA has loss of the H3K27 trimethylation and therefore loss of nuclear staining on H3K27me3 staining, while PFB group ependymoma tumor cells have retained nuclear expression. Answers A, C, D and E are incorrect because they do not distinguish H3K27 trimethylation status ...

2021年12月13日 · 90% are sporadic, with no established risk factors other than smoking in a subset of cases that harbor mutation signatures typical of smoking and mismatch repair deficiency (J Intern Med 2002;252:206, Cancer Cell 2016;29:723)

2023年9月29日 · Loss of H3K27me3; Negative for muscle markers Desmin expression seen in rhabdomyoblastic elements in malignant Triton tumor PEComa (Am J Surg Pathol 2005;29:1558, Int J Clin Exp Pathol 2019;12:4380): May show morphologic overlap with leiomyosarcoma Nested architecture or sheet-like growth pattern

2022年7月27日 · Glioblastoma, IDH wild type is an aggressive, infiltrating, astrocytic glioma that lacks mutations in IDH1, IDH2 and histone H3 genes and is histologically defined by brisk mitotic activity and microvascular proliferation or necrosis