H3K27M突变型胶质瘤的治疗和疗效监测 - 知乎 - 知乎专栏
H3K27M突变型弥漫性中线胶质瘤（diffuse midline glioma，DMG）是WHO中枢神经系统（CNS）恶性肿瘤分类2016年版中新增的脑肿瘤。 DMG发生于脊髓、脑干、松果体区和丘 …
Characteristics of H3 K27M-mutant gliomas in adults - PMC
As recently reported, H3 K27M-mutant gliomas can display a broad spectrum of histological features, including giant, epithelioid, and rhabdoid cells; primitive neuroectodermal tumor–like …
The landscape of tumor cell states and spatial organization in H3-K27M ...
2022年11月21日 · Here, through dissecting the single-cell transcriptomic, epigenomic and spatial architectures of a comprehensive cohort of patient H3-K27M DMGs, we delineate how age …
Pathology Outlines - Diffuse midline glioma, H3 K27 altered
2022年4月14日 · WHO 2021 definition: diffuse midline glioma, H3 K27-altered, is an infiltrative midline glioma with loss of H3 p.K28me3 (K27me3) and usually, either an H3 c.83A>T p.K28M …
[研究]不容忽视的H3K27M突变 在胶质瘤致病及诊疗中的作用 | 牛 …
2018年4月10日 · 最新研究发现，组蛋白h3.3特定位点的突变h3k27m导致氨基酸的改变与中线结构胶质瘤发生密切相关，且具有明显弥漫性生长的特点，恶性程度高。
A H3K27M-targeted vaccine in adults with diffuse midline glioma
2023年9月21日 · Substitution of lysine 27 to methionine in histone H3 (H3K27M) defines an aggressive subtype of diffuse glioma. Previous studies have shown that a H3K27M-specific …
Histone H3K27M Mutation in Brain Tumors - PubMed
In this chapter, we will review and summarize recent studies on the H3K27M-driven tumorigenic mechanisms and properties and the role of H3.1K27M and H3.3K27M oncohistones in brain …
Diffuse hemispheric glioma with H3 p.K28M (K27M) mutation: …
Diffuse midline glioma, H3 K27-altered (DMG-H3 K27) is an aggressive group of diffuse gliomas that predominantly occurs in pediatric patients, involves midline structures, and displays loss …
The histone H3.3 K27M mutation suppresses …
2025年1月20日 · We show that patient-derived H3.3 K27M tumor cells have decreased mitotic Ser31 phosphorylation and increased frequency of chromosome missegregation. CRISPR …
Nat. Genet. | 组蛋白H3.3-K27M致瘤活性的分子机制 - 知乎
近日，Adrian P. Bracken研究组、Gerard L. Brien以及Steven M. Pollard研究组在《 Nature Genetics 》在线发表了一篇题为“Simultaneous disruption of PRC2 and enhancer function …