Mar 30, 2025 · GSDMB (Gasdermin B) is a Protein Coding gene. Diseases associated with GSDMB include Childhood-Onset Asthma and Oral Squamous Cell Carcinoma. An important paralog of this gene is GSDMA.

Mar 29, 2023 · The cryo-EM structure of the GSDMB pore reveals mechanisms by which GSDMB pore-forming activity is regulated by pathogenic bacteria and mRNA splicing.

Mar 11, 2023 · Gasdermin (GSDM)-mediated pyroptosis is functionally involved in multiple diseases, but Gasdermin-B (GSDMB) exhibit cell death-dependent and independent activities in several pathologies...

Gasdermin B (GSDMB) belongs to the gasdermin (GSDM) family which may adopt different mechanisms of intramolecular domain interactions to modulate their lipid-binding and pore-forming activities. The GSDM family has regulatory functions in cell ...

Jan 20, 2022 · Gasdermin B (GSDMB) is currently the least studied, and while its association with genetic susceptibility to chronic mucosal inflammatory disorders is well established, little is known about its functional relevance during active disease states.

Dec 10, 2024 · Title: GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis. Structural and functional insights into GSDMB isoforms complex roles in pathogenesis.

May 21, 2021 · Gasdermin B (GSDMB) belongs to a large family of pore-forming cytolysins that execute inflammatory cell death programs. While genetic studies have linked GSDMB polymorphisms to human disease, its function in the immunological response to pathogens remains poorly understood.

Mar 29, 2023 · Here, we report the cryogenic electron microscopy structures of human GSDMB in complex with Shigella IpaH7.8 and the GSDMB pore. The structure of the GSDMB–IpaH7.8 complex identifies a...

Apr 16, 2020 · Zhou et al. show that granzyme A cleaves and activates gasdermin B (GSDMB), a central player in the highly inflammatory cell death process known as pyroptosis (see the Perspective by Nicolai and Raulet). GSDMB expression was highly expressed in some tissues and could be up-regulated by interferon-γ.

Nov 23, 2023 · To exploit GSDMB antibiotic activity for gram-negative bacteria infection, it is essential first to characterize how GSDMB variants might differentially target internal and external bacteria membranes and host plasmatic or mitochondria membranes.