Granulomas afford a unique juxtaposition of activating T cells and mycobacteria-laden macrophages, and the temporal coincidence of T cell differentiation, granuloma consolidation, and reduction of M. tuberculosis growth in all animal models that mimic human disease suggests causality (North and Jung, 2004). It is important to emphasize that T ...

Potential sequence of events in tuberculosis (TB) granuloma progression identified by gene co-expression analysis. Unbiased analysis of RNA-sequencing data identified a seven-gene cluster unique to TB lymph nodes compared with the non-infectious granulomatous disease, sarcoidosis.

TB granulomas are organized structures composed of immune cells, that serve as the body's primary defense against the spread of Mycobacterium tuberculosis (Mtb). The immune landscape of TB granulomas involves a complex array of immune cells, including CD4 + and CD8 + T cells, B cells, NK cells, and others, which collectively influence the fate ...

2012年4月20日 · Caseating granulomas — which are thought to result from the necrotic breakdown of participating cells, especially macrophages — are a signature of active tuberculosis in immunocompetent hosts...

2014年12月1日 · The development of the granuloma and its subsequent degeneration and necrosis, is the hallmark of infection caused by Mycobacterium tuberculosis. These structures probably evolved as primitive particle responses, but in mammals they are facilitated by the emerging acquired immune response, in which cytokines and chemokines help control their ...

2024年12月9日 · Granulomas, organized aggregates of immune cells which form in response to <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>), are characteristic but not exclusive of tuberculosis (TB). Despite existing investigations on TB granulomas, the determinants that differentiate host-protective granulomas from …

2022年1月20日 · Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in infected tissues, the architecture and composition of which are thought to affect disease outcome.

Tuberculosis (TB) is an infectious disease that has plagued humankind since ancient times [1] and even nowadays is thought to be present as latent infection in almost a quarter of the world’s population [2].Even though it is preventable and usually curable, in 2022 it was the second leading cause of death from a single infectious agent (after COVID-19), [3].

3 天之前 · This study describes the impact of mycobacterial genetic diversity on host-infection phenotypes by assessing the effect of different M. tuberculosis lineages on granulomatous inflammation using a 3D in vitro granuloma model. Despite being descriptive and showing mostly correlative relationships, the findings are useful and provide some solid support regarding the functional impact of M ...

3 天之前 · The members of the Mycobacterium tuberculosis complex (MTBC) causing human tuberculosis comprise 10 phylogenetic lineages that differ in their geographical distribution. ... Using a human in vitro granuloma model combined with bacterial load assessment, microscopy, flow cytometry, and multiplexed-bead arrays, we observed considerable intra ...