Glycosylphosphatidylinositol (pronunciation ⓘ) or glycophosphatidylinositol (GPI) is a phosphoglyceride that can be attached to the C-terminus of a protein during posttranslational modification. The resulting GPI-anchored proteins play key roles in …

这类的蛋白质被称为糖基磷脂酰肌醇锚定蛋白（GPI-AP）。 在人体中，至少有150种蛋白质被鉴定为GPI锚定蛋白，广泛分布在各种类型的细胞中；这些GPI锚定蛋白参与很多生物学过程，包括膜相关酶活性（PLAP、Phospholipase B、Aspartic proteinase等）、细胞信号转导（CD55、CD59和钙通道调控亚基a2d1等）、细胞粘附（OPCML、CD56等）和抗原呈递（Thy-1、CD14 …

2024年11月12日 · GPI-APs exhibit unique and indispensable biological functions, as demonstrated by their fluidity, role in lipid rafts, role in intracellular trafficking, compartmentalization, and shedding potential. GPI-APs are anchored to the outer leaflet of the plasma membrane, allowing them to diffuse laterally with high fluidity.

2020年12月3日 · In this review, we shall discuss one type of transmembrane proteins: Glycosylphosphatidylinositol-Anchored Proteins (GPI-APs), with specific emphasis on those involved in tumor cells by evading immune surveillance and future applications for diagnosis and immune targeted therapy.

2019年8月28日 · GPI-anchored proteins (GPI-APs) play crucial roles in various processes, and more and more GPI-APs have been identified and studied. In this review, previous genomic and proteomic predictions of GPI-APs in Arabidopsis have been updated, which reveal their high abundance and complexity.

2014年1月1日 · In mammalian cells, many kinds of GPI-anchored proteins (GPI-APs) with various functions have been identified, including enzymes, ligands, receptors, adhesion molecules, complement regulators, and other immunological proteins (Ferguson et al. 2009). GPI-AP precursors possess a GPI-anchor attachment signal at the carboxyl-terminus.

2022年8月17日 · Glycosylphosphatidylinositol (GPI) anchoring is a common protein modification that targets proteins to the plasma membrane (PM). Knowledge about the GPI lipid tail, which guides the secretion of GPI-anchored proteins (GPI-APs), is limited in plants.

2021年10月10日 · The glycosylphosphatidylinositol (GPI)-anchor modification attaches a lipid anchor to the C-terminus of a protein, tethering the protein to the cell surface membrane. From this membrane-bound state, GPI-anchored proteins (GPI-APs) can be released into the...

Human cells encode fi over 150 GPI-anchored proteins (GPI-APs) including cell surface receptors, complement regulators, transcytotic transporters, enzymes/inhibitors, and adhesion...

2016年6月14日 · Glycosylphosphatidylinositol-anchored proteins (GPI-AP) are important players in reception and signal transduction, cell adhesion, guidance, formation of immune synapses, and endocytosis. At that, a particular GPI-AP can have different activities depending on a ligand.