Polyvalent DNA gold nanoparticles, now more commonly referred to as spherical nucleic acids, [1] (Fig. 1) are colloidal gold particles densely modified with short (typically ~30-mer or less), highly oriented, synthetic DNA strands.

Our study represents a significant advancement in understanding the intricate interactions between gold nanoparticles and DNA, particularly focusing on the direct time-dependent DNA damage without the presence of ROS. We utilized AFM imaging and real-time molecular dynamics to observe and analyze the events occurring in the molecular environment.

2024年11月1日 · Coupling between fluorescent DNA probes and noble metal nanoparticles (NPs), especially gold nanoparticles (AuNPs), represents a hot topic in the field of nanotechnology and multiple fluorescence-based applications, such as sensing and imaging, based on such hybrid nanomaterials have been reported in the past years [[1], [2], [3], [4]].

2019年10月2日 · Inspired by nature’s ability to hybridize DNA, DNA-mediated self-assembled gold-DNA nanostructures (~200 nm) were designed and fabricated in this work. As illustrated in Fig. 1, the sunflower-like nanostructures exhibited strong NIR absorption and photothermal conversion ability.

2016年9月16日 · Here we show a directed crystallization of gold by a single DNA molecular regulator in a sequence-independent manner and its applications in three-dimensional topological controls of...

Gold nanoparticles (AuNPs) are tiny particles of gold with a size of 1–100 nm (Cao et al., 2022). AuNPs have attracted extensive attention due to their special physical and chemical properties (Zha et al., 2021), which are different from the counterpart bulk materials and small molecules.

2024年5月28日 · In this article, the current understanding of the adsorption of DNA to gold nanoparticles is summarized, and related applications in bioconjugation of DNA to gold surface is described. In addition, problems of using gold nanoparticles to …

2015年1月30日 · Monovalent DNA–gold nanoparticle (mDNA–AuNP) conjugates hold great promise for widespread applications, especially the construction of well-defined, molecule-like nanosystems. Previously...

2024年6月1日 · DNA-functionalized nanomaterials represent the cutting edge of the convergence between nanoscience and life sciences. The gold nanoparticles (AuNPs), with their versatile attributes, serve as multifunctional carriers in complex environments, supporting diverse physiological activities of DNA.

DNA-functionalized gold nanoparticles (DNA–AuNPs) and nanorods (DNA–AuNRs) have emerged as key yet versatile biomaterials for applications in biosensing, diagnostics and programmable assembly. The high cost and sometimes complex procedures of functionalization of DNA onto AuNPs and AuNRs via the Au−thiol interaction may have set a ...