Sans Plexin-B1, Glial Net Tightens Around Plaques - ALZFORUM
2024年6月1日 · In APP/PS1 controls (left), astrocytes (green) and microglia (brown) form a wide glial net around plaques. Without Plexin-B1 to enforce cell spacing (right), glia crowd together …
Glial Cell Communities Conspire to Drive Alzheimer’s Disease
2024年9月26日 · Less well understood is what role inflammation and glial changes play. Now, by analyzing single-nuclei RNA-Seq data from more than 400 postmortem brains, scientists have …
While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh
2024年2月27日 · The daily transfer of lipids from neurons to glia required neuronal lazarillo (NLaz), a fly apolipoprotein similar to human apolipoprotein E (APOE): knocking down NLaz …
“iAssembloids” Probe Glial Roles in Neuron Survival
2025年1月24日 · Interestingly, they discovered that this axis is undetectable in 2D or even 3D neuron monoculture models, highlighting the need for more sophisticated models replicating …
Neuron-Glia Crosstalk Underlies Senescence, Impaired Lipid
2024年6月7日 · The authors provide evidence that lipid droplets that accumulate in aged brains are sourced by lipids from the senescent glia themselves (cell autonomous), while others …
Newborn Neurons in the Adult Brain: Real Deal, or Glial Imposters?
2018年4月12日 · Glial Impostor? DCX+ (green) cells co-expressing the oligodendrocyte marker Olig2 (red). [Courtesy of Sorrells et al., Nature, 2018.] The researchers concluded that …
Primary Mixed Glial Cultures From Mouse Cerebral Cortex
2010年9月7日 · This protocol describes the preparation of primary glial cultures consisting of ~75% astrocytes and ~25% microglia. The protocol specifies neonatal mouse cerebral cortex, …
Amelioration of Tau and ApoE4-linked glial lipid ... - ALZFORUM
2023年11月29日 · This paper provides an important proof of concept for the role cholesterol has in mediating the effects of ApoE4 on Tau pathology. This effect might be driven through glial …
Do APOE4’s Lipid Shenanigans Trigger Tauopathy? | ALZFORUM
2023年11月29日 · Gene expression studies confirmed that GW3965 treatment normalized glial lipid metabolism, as well as helping neurons maintain synapse function and better degrade …
Regulation of cell distancing in peri-plaque glial nets by
2024年6月5日 · Important features of signaling within the glial nets—e.g., the identity of the Plexin-B1 ligand, how Plexin-B1 activation in astrocytes affects the physiology of …