Galectin-3 (Gal-3) is also a member of the beta-galactoside-binding protein family that plays an important role in cell-cell adhesion, cell-matrix interactions, macrophage activation, angiogenesis, metastasis, apoptosis. Galectin-3 is encoded by a single gene, LGALS3, located on chromosome 14, locus q21–q22.

Gal-3是一种可溶性的β-半乳糖苷结合蛋白，广泛分布在心、肾、肝、肺及肠道等组织器官中，在被激活的巨噬细胞、嗜碱性粒细胞和肥大细胞中高度表达，其主要定位于细胞质…

Galectin-3 is a member of the galectin family, which are β-galactoside-binding lectins with ≥1 evolutionary conserved carbohydrate-recognition domain. It binds proteins in a carbohydrate-dependent and -independent manner.

Galectin-3 (Gal-3) regulates basic cellular functions such as cell–cell and cell–matrix interactions, growth, proliferation, differentiation, and inflammation. It is not surprising, therefore, that this protein is involved in the pathogenesis of many relevant human diseases, including cancer, fibrosis, chronic inflammation and scarring ...

2022年7月20日 · Galectin-3 (Gal-3) is a pleiotropic protein that binds to β-galactoside residues present in glycoproteins. Gal-3 is mainly expressed and released in the damaged brain by reactive microglia....

该研究解析了半乳糖凝集素3通过诱导肠癌细胞中蛋白酶的分泌，继而加强了癌细胞的侵略性同时降低了癌细胞间上皮间质的完整性，证实了半乳糖凝集素3调控相关蛋白酶的分泌，对肠癌细胞扩散产生了的重要影响。 通过运用蛋白酶芯片，研究人员在人类肠癌细胞中发现，半乳糖凝集素3组中一些蛋白酶分泌有显著的提升，其中包括了几组 基质金属蛋白酶 以及 组织蛋白酶 （图一）。 基质金属蛋白酶（Matrix metalloproteinases， MMP）被认为是分基质金属蛋白酶解细胞外基质 …

2023年6月28日 · Galectin (Gal)-3 is a β-galactoside-binding lectin emerging as a key player in cardiac, hepatic, renal, and pulmonary fibrosis and inflammation, respiratory infections caused by COVID-19, and neuroinflammatory disorders. Here, we review recent information highlighting Gal-3 as a relevant therapeutic target in these specific disease conditions.

Galectin-3 is a β-galactoside-binding lectin which is important in numerous biological activities in various organs, including cell proliferation, apoptotic regulation, inflammation, fibrosis, and host defense. Galectin-3 is predominantly located in ...

Galectin-3 is structurally unique among all galectins as it contains a C-terminal CRD linked to an N-terminal protein-binding domain, being the only chimeric galectin. Galectin-3 participates in many functions, both intra- and extracellularly. Among them, a prominent role for Galectin-3 in inflammation has been recognized.

2022年12月8日 · We show that galectin-3 senses lipopolysaccharide (LPS) to facilitate the interaction of Rag GTPases and Ragulator, leading to the activation of mTORC1.