Galectin-1 is a protein that in humans is encoded by the LGALS1 gene. [5][6] LGALS1 contains four exons. The galectin-1 protein is 135 amino acids in length and highly conserved across species. It can be found in the nucleus, the cytoplasm, …

2023年1月16日 · Galectin-1 knockout showed shorter survival and an increased yeast burden after intratracheal infection, which was associated with a role of galectin-1 in limiting pro-inflammatory cytokine ...

Galectin-1作为一种有效的稳态信号，与其他抗炎介质和RAMP一起，限制免疫病理。 包括：1）抑制急性炎症；2）抑制T细胞介导的自身免疫性疾病；3）改善 移植物抗宿主病 ；4）使免疫反应的特征偏向于 Th2型 。

Galectin-1是凝集素家族中第一个被发现的成员，它含有一个或两个糖识别结构域（carbohydrate recognition domains, CRD）。 Galectin-1表达于多种类型的细胞，如 胸腺上皮细胞 、内皮细胞、树突状细胞、巨噬细胞、纤维母细胞和 骨髓基质细胞 等。

2006年7月13日 · Galectins are a family of carbohydrate-binding proteins with an affinity for β-galactosides. Galectin-1 (Gal-1) is differentially expressed by various normal and pathological tissues and appears to be functionally polyvalent, with a wide range of biological activity. The intracellular and extracellular activity of Gal-1 has been described.

2016年9月16日 · Galectin-1, a member of the galectin family of lectins, is a functionally dimeric galactoside-binding protein. Although galectin-1 has both intracellular and extracellular functions, the defining carbohydrate-binding role occurs extracellularly. In this review, the extracellular roles of galectin-1 in cancer processes are discussed.

2025年3月25日 · Galectin-1. The gene encoding Galectin-1 (Gal-1), LGALS1, is located on chromosome 22q13.1 (Fig. 1B) . This gene is composed of four exons that are spliced to form a 0.6 kb transcript (GenBank: NM_002305). The resulting translation product is the Gal-1 protein with a molecular weight of 14.5 kDa.

Galectin-1 (Gal-1), a member of the β-galactoside-binding soluble lectin family, is a double-edged sword in immunity. On one hand, it plays a crucial role in regulating diverse immune cell functions, including the apoptosis of activated T cells. These processes are key in resolving inflammation and preventing autoimmune diseases. On the other hand, Gal-1 …

5 天之前 · By identifying a nuclear role for Galectin-1 (Gal1) in regulating the transcription of oncogenic genes such as KRAS, we uncover a critical mechanism driving PSC activation and the secretion of protumorigenic factors. Given the central role of tumor-stroma crosstalk in PDAC progression and its contribution to therapy resistance, these results ...

Galectin‐1(Gal1), a tandem repeat‐type of 14‐kDa protein, is highly expressed and secreted into the milieu by a spectrum of primary and metastatic tumors. In addition, Gal1 is characterized by two carbohydrate recognition domains that extensively bind to the glycolipid or glycoprotein on the cell surface, thus modulating a cascade of ...