三肽谷胱甘肽 (gsh) 是细胞中最丰富的非酶抗氧化剂/亲核分子。除了涉及 gsh 及其氧化对应物 gssg 的各种代谢反应外，蛋白质的氧化翻译后修饰（ptm）在过去几十年中一直是氧化还原领域广泛关注的焦点。

2022年2月10日 · We report that in chow-fed, reproductively senescent female mice but not in age-matched male mice, deficiency in the thiol transferase glutaredoxin 1 (Grx1) promotes dysregulated macrophage...

2018年1月22日 · We found that Grx1 silencing significantly decreased the cellular GSH/GSSG ratio, leading to excessive ROS production. Our results propose that the increased glutathionylation of DJ-1 and HSP60 may compromise the mitochondrial SRC and OCR and increase susceptibility of cells to oxidative stress.

2008年5月11日 · Here we demonstrate that the fusion of roGFP2 and human glutaredoxin-1 (Grx1) allows dynamic live imaging of intracellular glutathione redox potential, EGSH, with unprecedented sensitivity and...

在氧化应激状态下，蛋白质上的半胱氨酸残基（-SH）发生 S-谷胱甘肽化，这是一个可逆的过程。 其去谷胱甘肽化主要由 谷氧还蛋白 （Glutaredoxin-1，Grx1）催化 [2]。 最近的研究表明，蛋白质 S-谷胱甘肽化和 Grx1 与急性肺损伤（ALI）密切相关 [3] ，但Grx1 驱动的调节急性肺损伤的机制仍 …

2021年7月1日 · Grx1, via its deglutathionylase activity, regulates DJ-1 activity, avoiding its degradation which correlates with neuroprotection [162]. Indeed, Grx1 knockout mice show increased glutathionylation and loss of function of DJ-1 which, in SH-SY5Y and C. elegans causes dopaminergic neuron loss, a feature associated to PD [162].

2023年8月1日 · Grx1 has two GSH binding sites, a GSH scaffold site (cyan) and a GSH activator site (including K19, pink), with catalytic C23 that forms disulfide with GSH during deglutathionylation (PDB: 1B4Q). α-chloroacetamide-containing Grx1 inhibitor, CWR-J02, was developed that covalently inhibits Grx1. 7-mer peptide Grx1 inhibitor (ETRWPNT, named 2GTP1 ...

The thioredoxin-1 (Trx1) and the glutathione (GSH)/glutaredoxin-1 (Grx1) systems are key players in preserving cytosolic redox balance. In fact, T lymphocytes critically rely on reducing equivalents from the Trx1 system for DNA biosynthesis during metabolic reprogramming upon activation.

2014年5月11日 · Glutaredoxin1 (GRX1) is a glutathione (GSH)-dependent thiol oxidoreductase. The GRX1/GSH system is important for the protection of proteins from oxidative damage and in the regulation of protein function. Previously we demonstrated that GRX1/GSH regulates the activity of the essential copper-transporting P1B-Type ATPases (ATP7A, ATP7B) in a ...

2021年11月1日 · Trx and related antioxidant enzymes are specifically localized to different subcellular organelles in neuronal and glial cells and locally control redox signaling. The Trx1 system, coupled with Prx1/2 and MSR, and the GSH-Grx1 system, coupled with GPx1, regulate redox signaling in the cytosol and nucleus.