2023年11月11日 · 简介 葡萄糖调节蛋白 78kD (GRP78) 是一种分子伴侣，也是 ER 应激反应的主要调节因子，该反应由多种干扰 ER 中蛋白质折叠的条件触发。 在内质网应激时，GRP78 会激活未折叠蛋白反应 (UPR)，其目的是清除未折叠蛋白并恢复内质网稳态。 最近，描述了 GRP78 的细胞外分泌。 然而，分泌型 GRP78 在动脉粥样硬化和内皮细胞炎症中的病理生理学相关性仍有待阐明。 本研究的目的是探讨 GRP78 分泌在内皮细胞中的作用。 方法和结果 首先，我们试图研 …

GRP78/BiP is a major endoplasmic reticulum (ER) chaperone protein critical for protein quality control of the ER, as well as controlling the activation of the ER-transmembrane signaling molecules. Through creation of mouse models targeting the Grp78 allele, the function of GRP78 in development and disease has been investigated. These led to the ...

The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum (ER)-resident molecular chaperone. GRP78 is a member of the 70 kDa heat shock family of proteins involved in correcting and clearing misfolded proteins in the ER. In response to cellular stress, GRP78 escapes from the ER and mo …

2019年2月12日 · Glucose regulatory protein 78 (GRP78), the master regulator of the UPR, plays a role in proliferation, invasion, and metastasis in cancer. Cancer stem cells (CSCs)...

GRP78 is the master of the unfolded protein response (UBR) in the Endoplasmic Reticulum (ER) in normal cells. GRP78 force the unfolded proteins to refold or degrade using cellular degradation mechanisms. Under stress, the overexpression of GRP78 on the cell membrane mediates the vast amount of disordered proteins.

2020年4月11日 · PERK （Protein kinase R （PKR）-Like Endoplasmic Reticulum Kinase） 是一种 Ser/Thr （丝氨酸/苏氨酸） 蛋白激酶， 其催化结构域与其它真核起始因子 2α （eIF2α） 家族的激酶具有高度同源性。Grp78 一旦释放，PERK 开始在 ER 膜内低聚激活，诱导其自磷酸化并激活 …

2019年6月1日 · GRP78 is the master of the unfolded protein response (UBR) in the Endoplasmic Reticulum (ER) in normal cells. GRP78 force the unfolded proteins to refold or degrade using cellular degradation mechanisms. Scope: Under stress, the overexpression of GRP78 on the cell membrane mediates the vast amount of disordered proteins. Unfortunately, this ...

GRP78 BiP (HSPA5)靶点介绍及实验小贴士靶点介绍助您了解其蛋白功能，蛋白特性，蛋白定位及异构体和翻译后修饰等特质。 同时列举了实用的WB实验小贴士，助您实验成功。

grp78 在癌细胞和血管生成内皮细胞的表面过度表达，这使其成为不同类型的肽和抗体的有希望的靶标，可用于靶向癌症治疗或成像。 在这篇综述中，我们讨论了肿瘤细胞中细胞表面 GRP78 (csGRP78) 的生物学过程、功能重要性和易位机制。

2021年5月7日 · The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum (ER)-resident molecular chaperone. GRP78 is a member of the 70 kDa heat shock family of proteins involved in correcting and clearing misfolded proteins in the ER.