Acute GVHD leads to substantial gastrointestinal symptom burden, including profuse diarrhoea, abdominal pain, severe malnutrition and gastrointestinal bleeding; providing supportive and palliative care is a critical role of the gastroenterologist

The original histopathologic description of chronic graft-versus-host disease (CGVHD) of the gastrointestinal (GI) tract was from autopsy series. There is little information on the evaluation of living patients with CGVHD and GI symptoms. We reviewed data on 40 consecutive patients with CGVHD and pe …

2023年2月21日 · In graft vs. host disease (GvHD), the donated stem cells you receive during an allogeneic stem cell transplant view your body’s cells as a threat and attack. There are two main types of GvHD: acute GvHD and chronic GvHD. Treatments include drugs that suppress (calm) your immune system.

2016年3月24日 · Lower and time-limited doses of immune suppression for patients predicted to have low-risk GVHD are safe and effective. In more severe GVHD, prolonged exposure to immunosuppressive therapies, failure to achieve tolerance, and inadequate clinical responses are the proximate causes of GVHD-related deaths.

2023年6月8日 · Acute graft-versus-host disease (GVHD) is classified as classic acute GVHD with onset ≤100 days after allogeneic haematopoietic cell transplantation (alloHCT), as late onset acute...

2023年8月3日 · Acute gastrointestinal graft versus host disease (GI-GVHD) is a common complication following allogeneic haematopoietic cell transplantation (HCT), and is...

2017年12月7日 · A frequent complication of HSCT is acute graft-versus-host disease (GVHD), a condition in which immune cells from the donor attack healthy recipient tissues. The gastrointestinal system is among the most common sites affected by acute GVHD, and severe manifestations of acute GVHD of the gut portends a poor prognosis in patients after HSCT.

2016年4月15日 · gvhd 的治疗具有一定风险，因此需要明确诊断 gvhd，诊断时应联合多个指标：高度发生 gvhd 可能；无感染证据；体格检查、肠道影像学和肠粘膜内镜检查结果一致；肠道陷窝和小胆管典型的组织学改变。

2018年11月6日 · Acute gastrointestinal (GI) graft-versus-host disease (GvHD) is a life-threating complication in patients after allogeneic stem cell transplantation...

It is essential to accurately record the grade AND organ-specific stage of acute GVHD in the EPR and to review this regularly. Where acute GVHD severity increases, the new grade and organ stage should be reported. Where a patient responds to treatment, it is also important to indicate how they have responded using the same system.