在T-B交界处，TFH与具有高抗原亲和力的B细胞结合，分泌细胞因子刺激B细胞，后者迁移回到B细胞区并大量增殖，形成生发中心（germinal center，GC 和长头发一点关系都没有！ 进入以后，B细胞继续受到 滤泡树突状细胞 （follicular dendritic cells, FDC）分泌的CXCL13（也是一种chemokine，能被B细胞表面受体CXCR5识别）影响来到初级淋巴滤泡（primary lymphoid follicle）中。 B细胞的成熟需要抗原和细胞因子共同刺激。

2021年8月10日 · Germinal center (GC) B cells are the source of the high-affinity, class-switched antibodies required for protective immunity. The unique biology of GC B cells involves iterative rounds of antibody gene somatic hypermutation coupled …

There are two major biologically distinct molecular subtypes of DLBCL: germinal center B-cell (GCB) and activated B-cell (ABC). ABC DLBCL is associated with substantially worse outcomes when treated with standard chemoimmunotherapy.

2021年5月24日 · Maturation of B cells within germinal centers (GCs) generates diversified B cell pools and high-affinity B cell antigen receptors (BCRs) for pathogen clearance.

2015年2月25日 · Germinal centres (GCs) are involved in the selection of B cells secreting high-affinity antibodies and are also the origin of most human B cell lymphomas. Recent...

2011年9月6日 · Here we show a new culture system in which mouse naïve B cells undergo massive expansion and isotype switching, and generate GC-phenotype B (iGB) cells. The iGB cells expressing IgG1 or...

2000年6月1日 · To better understand the differentiative processes occurring within murine GCs, we sought to identify subpopulations of GC B cells corresponding to discrete stages of GC B cell ontogeny. We performed multiparameter flow-cytometric analyses of GC B cells at consecutive time points following immunization of BALB/c mice with SRBC.

2021年8月10日 · Germinal center (GC) B cells are the source of the high-affinity, class-switched antibodies required for protective immunity. The unique biology of GC B cells involves iterative rounds of antibody gene somatic hypermutation coupled …

3 天之前 · GCB cells enriched from the spleen of Cγ1Cre tg/+-Fbxo45 +/+, Cγ1Cre tg/+-Fbxo45 +/fl, and Cγ1Cre tg/+-Fbxo45 fl/fl transgenic mice were analyzed by flow cytometry 10 days after immunization with sheep red blood cells (SRBC), a T cell–dependent antigen that evokes a robust GC response and is required to induce the expression of Cre.

2024年7月26日，清华大学生命学院江鹏课题组在《自然·化学生物学》（Nature Chemical Biology）期刊上以长文的形式发表了题为“生发中心B细胞形成和反应的代谢决定因素”（Metabolic determinants of germinal center B-cell formation and responses）的研究论文。