2024年5月6日 · Glioblastoma multiforme (GBM) is the most malignant and pervasive subtype of glioma and is the most common primary brain tumor in adults. It remains an incurable disease with a median survival of 15 months and has been classified into wild-type and mutant isocitrate dehydrogenase (IDH) subtypes.

2017年9月27日 · Glioblastoma (GBM) is the most aggressive diffuse glioma of astrocytic lineage and is considered a grade IV glioma based on the WHO classification (1). GBM is the most common malignant primary brain tumor making up 54% …

The mean age of primary GBM presentation is 62 years, and the median survival is approximately 14.6 months [1,3]. The poor prognosis associated with GBM is well documented, while survival rates remain disappointingly low despite medical and surgical advances.

Glioblastoma multiforme (GBM) is a WHO grade IV glioma and the most common malignant, primary brain tumor with a 5-year survival of 7.2%. Its highly infiltrative nature, genetic heterogeneity, and protection by the blood brain barrier …

2024年5月6日 · Glioblastoma multiforme (GBM) comprises glioma's most malignant and pervasive subtype. GBM is the most common primary brain tumor in adults, accounting for 45.2% of primary malignant brain and central nervous system (CNS) tumors. Magnetic resonance imaging (MRI) shows poorly circumscribed marginal e …

This review describes how STAT-3 activation and resulting downstream effects play a role in GBM progression, and how therapeutic strategies to inhibit STAT-3 signaling provide new opportunities for GBM treatment.

2025年3月26日 · Glioblastoma (GBM) is a primary malignant brain tumor of the central nervous system, with a high degree of malignancy and an annual incidence of 3–5 per 100,000 people 1.Even with the most ...

2025年2月26日 · Glioblastoma multiforme (GBM) is the most prevalent and aggressive primary brain tumor in adults, characterized by a poor prognosis and significant resistance to existing treatments. Despite progress in therapeutic strategies, the median overall survival remains approximately 15 months. A hallmark of GBM is its intricate molecular profile, driven by disruptions in multiple signaling pathways ...

2025年3月28日 · Glioblastoma (GBM) is the most common and lethal brain tumor with limited therapeutic strategies and incomplete studies on its progression and mechanisms. ... Statistics of the number of people ...

2024年7月17日 · Glioblastoma (GBM) is one of the most complex, deadly, and treatment-resistant cancers. More than 14,490 Americans are expected to receive a GBM diagnosis in 2023. GBM accounts for 50.1 percent of all primary malignant brain tumors. It is estimated that more than 10,000 individuals in the United States will succumb to glioblastoma every year.