2025年3月30日 · G3BP1 (G3BP Stress Granule Assembly Factor 1) is a Protein Coding gene. Diseases associated with G3BP1 include Chikungunya and Glioma Susceptibility 1 . Among its related pathways are SARS-CoV-2 Infection and Infectious disease .

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene. [5] [6] [7] This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion.

2020年4月17日 · Jude Children’s Research Hospital的J. Paul Taylor组，题目为G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules。 杨培国 博士等人首次在全基因组范围内筛选出了调控SG形成的重要蛋白组分，系统的研究了参与SG形成的蛋白网络以及重要组分在其形成中的作用。

2020年4月16日 · Biophysical studies revealed details of how G3BP1 functions as a molecular switch that triggers RNA-dependent LLPS. Importantly, interplay between three distinct intrinsically disordered regions (IDRs) in G3BP1 regulates its intrinsic propensity for LLPS, and this is fine-tuned by phosphorylation within the IDRs.

2018年12月3日 · Here we report that GTPase-activating protein SH3 domain–binding protein 1 (G3BP1) is critical for DNA sensing and efficient activation of cGAS. G3BP1 enhanced DNA binding of cGAS by promoting...

2020年4月16日 · Here, we show that SGs assemble through liquid-liquid phase separation (LLPS) arising from interactions distributed unevenly across a core protein-RNA interaction network. The central node of this network is G3BP1, which functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations.

根据这项研究，目前已知 G3BP 将结节性硬化复合体 (TSC) 与溶酶体连接在一起，并通过分子组雷帕霉素靶蛋白复合体 1 (mTORC1) 来抑制信号转导。 这一发现的意义重大，因为 mTORC1 过度活化与典型特征为细胞过度生长、迁移和神经元兴奋性的疾病有关。 因此 G3BP 可能是癌症和神经元疾病的重要治疗靶标。 所有 CST 抗体均根据 Hallmarks of Antibody Validation™ 进行了严格验证，因此研究人员能够高效地获得明确的结果。 这包括对 G3BP 与 TSC 复合体之间的物理相 …

Ras-GTPase-activating protein (GAP)-binding protein 1 (G3BP1) is a multi-functional protein that is best known for its role in the assembly and dynamics of stress granules. Recent studies have highlighted that G3BP1 also has other functions related to RNA metabolism.

2021年6月29日 · 对于应激颗粒来说，G3BP1和G3BP2是为建立应激颗粒组装的渗滤阈值提供最大贡献的蛋白质。 尽管在理解应激颗粒组装的分子基础方面已经取得了很大的进展，但对支配其消除的机制却知之甚少。 鉴于许多导致神经变性的突变都会导致应激颗粒的清除障碍，这一过程就显得特别有意义。 在一篇伴随的报告中发现，当热休克诱导应激颗粒聚集时，G3BP1被泛素化，而当细胞暴露于其他类型的诱导应激颗粒产生的应激因素时，G3BP1没有发生泛素化。 这一发现 …

2021年1月27日 · Ras-GTPase激活蛋白结合蛋白1和2（G3BP1、G3BP2）以非冗余的方式将Tuberous Sclerosis Complex（TSC）锚定在溶酶体上，并通过氨基酸和胰岛素抑制mTOR复合物1（mTORC1）激活。