2020年3月9日 · This document discusses fibroblast growth factor receptors (FGFRs) and FGFR inhibitors. It provides details on FGFR signaling pathways and the role of FGFRs in various …

The FGFRs are receptors that bind to members of the FGF family of proteins. The receptors consist of an extracellular ligand domain with three immunoglobulin- like domains (I-III), A …

肿瘤中 ERKs调节着细胞的增殖、分化和存活，是多 种生长因子（EGF、NGF、PDGF等）的下游蛋白，ERK 和其信号途径在肿瘤侵袭和转移过程中起中介和放大信号 的作用，一方面接受大 …

2012年12月24日 · Fibroblast Growth Factor Receptor 2 (FGFR-2) has more than 20 alternative splicing isoforms. FGFR-2 expression and genetic alterations have been reported in various …

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Western blot analysis using immunoprecipitated iFGFR1 and total cell lysates showed that both PD (20 nM) and FIIN-1 (20 nM) inhibited iFGFR1 autophosphorylation and its downstream …

2017年8月15日 · Wt/cont +Fgf8 +sFgfr3 Fgfr3* Fgfr3 ko Differential signaling via multiple Fgf ligands Fgf8/15/17 Fgf2.. and other Fgfs Differential signaling via Fgfr gradients (e.g. Fgfr3) …

S161. H114. E115. K91. Q173. R93. D171. Fragment- based approaches to the design of candidate drugs that interrupt protein-protein interactions involved in cell regulation. Cdk6. …

Molecular roots of FGFR3-related skeletal dysplasia. Pavel Krejci , PhD Institute of Experimental Biology, Masaryk University, Brno Department of Cytokinetics, Institute of Biophysics AVCR, …

2013年3月26日 · Fibroblast Growth Factor Receptor 2 (FGFR-2) has more than 20 alternative splicing isoforms. FGFR-2 expression and genetic alterations have been reported in various …