Humans express a long FFAR4 protein isoform consisting of 377 amino acids and a short splice variant protein isoform consisting of 361 amino acids. However, rodents, non-human primates, …

In humans, there are two FFAR4 splice variants: the long (L) and short (S) isoforms, which differ due to the insertion of 16 amino acids in the third intracellular loop. Some reports suggest that …

2024年2月2日 · In this study, we found that Ffar4 expression is down-regulated in MetS mice and MetS patients with cognitive impairment. Conventional and microglial conditional knockout of …

2021年4月7日 · Free fatty acid receptors (FFARs) are a class of G protein-coupled receptors (GPCRs) that have wide-ranging effects on human physiology. The four well-characterized …

2024年12月24日 · Free fatty acid receptors (FFARs) play critical roles in metabolic regulation and are potential therapeutic targets for metabolic and inflammatory diseases. A comprehensive …

考虑到FFAR4在维持代谢稳态中的重要性和治疗糖尿病的潜力，该研究解决了天然配体DHA结合的FFAR4与miniGs和miniGsq复合物，合成激动剂gw9508结合的FFAR4与miniGsq复合物的冷 …

List of variants in gene FFAR4 reported as risk factor Minimum submission review status: ★☆☆☆ criteria provided ★★★☆ reviewed by expert panel ★★★★ practice guideline

2024年12月25日 · FFAR4 (Free Fatty Acid Receptor 4) is a Protein Coding gene. Diseases associated with FFAR4 include Body Mass Index Quantitative Trait Locus 10 and Retinal …

2022年2月21日 · Free fatty acid-activated receptors include FFAR1 (GPR40), FFAR2 (GPR43), FFAR3 (GPR41), and FFAR4 (GPR120). FFAR2 and FFAR3 are activated by short-chain fatty …

This review summarizes the current knowledge on the biology of FFAR1 (GPR40), FFAR2 (GPR43), FFAR3 (GPR41), FFAR4 (GPR120), and GPR84, including structural aspects of …