Crucial Role of Increased Arid3a at the Pre-B and Immature B Cell ...
In fetal/neonatal stages, increased Arid3a at the pre-B cell and immature B cell stages as a Lin28 + Let7 − outcome is crucial for generating B1a cells together with the environment for initial …
B-1a cells acquire their unique characteristics by bypassing the pre ...
2019年10月18日 · Although B-1a cells are known to primarily originate from fetal tissues, the mechanisms by which they arise has been a topic of debate for many years. Here we show …
B1a and B2 cells are characterized by distinct CpG ... - Nature
2021年4月13日 · Here we profile the CpG modifications and transcriptomes of peritoneal B1a and follicular B2 cells, as well as their respective proB cell precursors in the fetal liver and adult …
Development, phenotype, and function of non-conventional B cells
2017年10月1日 · Three populations of B cells develop in fetal life: B1, B2 and marginal zone B cells. B1 cells play important roles in innate immunity in contrast to B2 cells that perform the …
Single-cell genomics identifies distinct B1 cell developmental …
B1 cells are self-renewing innate-like B lymphocytes that provide the first line of defense against pathogens. B1 cells primarily reside in the peritoneal cavity and are known to originate from …
Postnatal regulation of B-1a cell development and survival by the …
2022年2月15日 · B-1 cell development mainly occurs via fetal and neonatal hematopoiesis and is suppressed in adult bone marrow hematopoiesis. However, little is known about the factors …
To B1a or not to B1a: do hematopoietic stem cells ... - ScienceDirect
2016年12月15日 · Powerful experimental approaches including bar coding, single cell transplantation, in vivo lineage tracing, and HSC-specific pulse-chase labeling have provided …
Control of B-1a cell development by instructive BCR signaling
2018年4月1日 · Premature Igk rearrangements in fetal pro-B cells can promote B-1a cell development. Bhlhe41, Aridr3a and Lin28b have emerged as key molecular regulators of B-1a …
To B1a or not to B1a: do hematopoietic stem cells contribute to …
We evaluate the evidence for fetal vs adult B1a-cell production capacity and the identity of putative cells of origin. Integrating these most recent findings with previous work, we propose …
We report that capicua (CIC) suppresses postnatal B-1a cell development and survival. CIC levels are high in B-1a cells and gradually increase in transitional B-1a (TrB-1a) cells with age. B-cell …