2023年3月8日 · The study results, published March 7 in Current Biology, reveal that female mice, despite ongoing hormonal fluctuations, exhibit exploratory behavior that is more stable than that of their male peers. Using a strain of mice commonly studied in lab settings, the researchers analyzed how the animals behaved as they freely explored an open space.

2023年4月5日 · To examine this question, Levy et al. used Mo-Seq, a machine learning algorithm that enables unbiased, high-dimensional analysis of mouse behavior, to profile adult C57BL/6J female mice...

2025年1月22日 · The maternal X chromosome in female mice impairs cognition through the silencing of certain genes and accelerates ageing of the hippocampus. Female mammalian cells have two X chromosomes, one...

2025年3月5日 · Old female mice had more PLP1 in the hippocampus than old male mice, suggesting that the extra PLP1 from the second X chromosome had made a difference. To test whether PLP1 could explain the resilience of the female brain, the team artificially expressed PLP1 in the hippocampus of female and male old mice. The extra PLP1 provided a brain boost ...

2023年3月7日 · The study results, published March 7 in Current Biology, reveal that female mice, despite ongoing hormonal fluctuations, exhibit exploratory behavior that is more stable than that of their male peers. Using a strain of mice commonly studied in lab settings, the researchers analyzed how the animals behaved as they freely explored an open space.

2023年6月7日 · Naive wild female mice often kill pups, while lactating female mice are dedicated to pup caring 3, 4. The neural mechanisms that mediate infanticide and its switch to maternal behaviours during...

The underrepresentation of female mice in neuroscience and biomedical research is based on the assumption that females are intrinsically more variable than males and must be tested at each of four stages of the estrous cycle to generate reliable data.

Here, we describe a novel female mouse model of CSS and a parallel modified male mouse model of CSDS in C57BL/6 mice. These new models enable the investigation of vulnerability, coping and downstream effectors mediating short-term …

2010年3月26日 · Male rats and mice have become the default animal model for many diseases because they are easier and cheaper to work with than females. Female rodents have a 4-day ovarian cycle, so researchers who use them must take daily vaginal swabs in experiments where hormones might play a role.

2023年3月7日 · A new study finds male mice more unpredictable than females, challenging century-old assumptions used to exclude females from research because of their hormones.