2024年12月25日 · FAT4 (FAT Atypical Cadherin 4) is a Protein Coding gene. Diseases associated with FAT4 include Van Maldergem Syndrome 2 and Hennekam Lymphangiectasia-Lymphedema Syndrome 2. Among its related pathways are Kidney development and Markers of kidney cell lineage. Gene Ontology (GO) annotations related to …

Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene. [5] [6] FAT4 is associated with the Hippo signaling pathway. [7]

对小鼠的研究表明，PCP 信号传导的缺失可能会导致囊性肾病，并且该基因的突变与 Van Maldergem 综合征 2 相关。 已注意到该基因的选择性剪接转录物变体。 [RefSeq 提供，2014 年 3 月] The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP).

2023年9月1日 · Here, we report the mechanism by which FAT4 overexpression regulates anti-tumor immunity in cervical cancer by inhibiting PD-L1 N-glycosylation and cell membrane localization in a β-catenin-dependent manner. Methods: FAT4 expression was first detected in cervical cancer tissues and cell lines.

2025年2月8日 · FAT4 loss initiates hepatocarcinogenesis through the switching of canonical to noncanonical WNT signaling pathways. Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients of Colon Cancer: Clinicopathologic Study. Identification of FAT4 as a positive prognostic biomarker in DLBCL by comprehensive genomic analysis.

Our study summarized and analyzed the antitumor effect of FAT4 in different tumors comprehensively, which aided in understanding the role of FAT4 in tumorigenesis from the perspective of clinical tumor samples. Pan-cancer analysis showed that FAT4 to be novel biomarkers for various cancers prognosis.

2015年12月3日 · FAT4, a cadherin-related protein, was shown to function as a tumour suppressor; however, its role in human gastric cancer remains largely unknown. Here, we investigated the role of FAT4 in...

The FAT4 gene provides instructions for making a protein that is found in most tissues. Learn about this gene and related health conditions.

原粘蛋白脂肪4 ，也称为钙粘蛋白家族成员14 （CDHF14）或脂肪肿瘤抑制剂同源物4 （FAT4），是一种蛋白质，在人类中被FAT4基因编码。 FAT4与河马信号通路有关。 临床意义. FAT4中的突变与Hennekam综合征有关。

2023年2月16日 · Here, we determine the co-crystal structure of the human homologs Fat4 and Dachsous1 (Dchs1) to establish the molecular basis for Fat-Dachsous interactions. The binding domains of Fat4 and...