Fas signaling downregulated epithelial markers, upregulated mesenchymal markers and promoted motility in gastrointestinal (GI) cancer cells. FasL treatment also increased the expression of EMT transcriptional factors in the nucleus and induced a spindle shape cell morphology in these cells.

2013年2月28日 · Fas signaling downregulated epithelial markers, upregulated mesenchymal markers and promoted motility in gastrointestinal (GI) cancer cells. FasL treatment also increased the expression of EMT transcriptional factors in the nucleus and induced a spindle shape cell morphology in these cells.

2020年10月26日 · FasL treatment inhibited E-cadherin transcription by upregulation of Snail in GI cancer cells. The nuclear expression and transcriptional activity of Snail and β-catenin were increased by inhibitory phosphorylation of glycogen synthase kinase-3 beta (GSK-3β) at Ser9 by FasL-induced extracellular signal-regulated kinase (ERK)/mitogen-activated ...

2008年5月5日 · To elucidate the mechanisms by which GAS and SS might influence apoptotic signaling pathway, we analyzed them effects on the expression of Fas, FasL, caspase-3 and caspase-8 protein in human LIC tissue. GAS is a gastrointestinal (GI) peptide that possesses potent trophic effects on most of the normal and neoplastic mucosa of the GI tract.

2003年3月25日 · Fas ligand (FasL), a member of the tumor necrosis factor family, initiates apoptosis by binding to its surface receptor Fas. As a consequence, there is sequential activation of caspases and the...

2014年11月15日 · Fas signaling promotes metastasis of gastrointestinal (GI) cancer cells by inducing epithelial-mesenchymal transition (EMT), and EMT acquisition has been found to cause cancer chemoresistance. Here, we demonstrated that the response to chemotherapy of GI cancer patients with higher expression of Fas …

The Fas ligand (Fasl), a member of the tumor necrosis factor family, induces apoptosis in Fas-bearing cells. The membrane-bound human Fasl was found to be converted to a

Fas ligand (FasL) is a molecule that induces Fas receptor mediated apoptosis of activated immunocytes, thereby mediating normal immune downregulatory roles including immune response termination, tolerance acquisition, and immune privilege.

2023年3月21日 · FasL是能够结合到死亡受体TNFRSF6/FAS的细胞因子，在T-cell发育中介导其由于细胞毒性引起的凋亡。FasL基因位于1号染色体，与OX-40L基因相邻，由5个外显子组成。FasL只表达于活化T淋巴细胞，其它细胞如B细胞、巨噬…

Fas signaling downregulated epithelial markers, upregulated mesenchymal markers and promoted motility in gastrointestinal (GI) cancer cells. FasL treatment also increased the expression of EMT transcriptional factors in the nucleus and induced a spindle shape cell morphology in these cells.