In immunology, an Fc receptor is a protein found on the surface of certain cells – including, among others, B lymphocytes, follicular dendritic cells, natural killer cells, macrophages, neutrophils, eosinophils, basophils, human platelets, and mast cells – that contribute to the protective functions of the immune system.

Fcγ受体（FcγR）是一类能与抗体Fc端结合的细胞表面受体，主要通过其ITAM激活序列在细胞内产生信号。 所有Fcγ受体都属于免疫球蛋白超家族。

FcRγ通常为二聚体结构，是一种跨膜蛋白，通过其跨膜结构和α链耦联，其胞内结构包含ITAM或者ITIM结构域，行使介导FcR信号通路的作用。 IgG类型抗体的Fc受体是FcγR，依据和Fc片段亲和力的强弱FcγR又可以被分为三个亚家族：FcγRI、FcγRII和FcγRIII；对于不同亚型的IgG，IgG1和IgG3能够有效的激活FcγR，对应的IgG2和IgG4激活FcγR的能力就较弱。 FcγRI (CD64) FcγRI的结构比较特殊，其胞外的α链中有三个串联的Ig结构，而其他的FcR的胞外架构一般有两个Ig结 …

On innate immune effector cells, activating and inhibitory FcγRs set a threshold for cell activation by immune complexes. Important examples for effector responses that are regulated by FcγRs are...

Fc-gamma receptors (FcγRs) recognize IgG-coated targets, such as opsonized pathogens or immune complexes (ICs). Cross-linking leads to internalization of the cargo with associated activation of down-stream signaling cascades.

Communication of IgG antibodies with the immune system is controlled and mediated by Fc gamma receptors (FcγRs), membrane-bound proteins, which relay the information sensed and gathered by antibodies to the immune system. These receptors are also glycoproteins and provide a link between the innate and adaptive immune systems.

The Fc-gamma receptors (FcγRs) are receptors for the Fc region of immunoglobulin (Ig)G, and are involved in a multitude of innate and adaptive immune responses, including mediating the specific recognition of antigens by leucocytes 1, 2.

Fc gamma receptors (FcγRs) are a family of receptors that bind IgG antibodies and interface at the junction of humoral and innate immunity. Precise regulation of receptor expression provides the necessary balance to achieve healthy immune ...

Fc gamma receptor (FcγR) is a receptor for the Fc portion of IgG. All of the Fc gamma receptors (FcγR) belong to the immunoglobulin superfamily. Fc gamma receptor is essential participant in many immune system effector functions, such as phagocytosis of opsonized, release of inflammatory mediators and antibody-dependent cellular cytotoxicity.

2023年4月20日 · FcγR与免疫球蛋白G（IgG）分子结合后，可以激活免疫细胞的吞噬作用，从而起到免疫调节和维护机体健康的作用。 FcγR介导的吞噬作用是机体免疫系统最直接和有效的免疫清除方式之一。 在免疫应答中，当被它识别的IgG结合特异性抗原时，FcγR就会被激活，并通过调节巨噬细胞、树突状细胞和NK细胞的吞噬行为，将病原体、细胞垃圾、肿瘤细胞等吞噬并消化掉。 这种吞噬作用的效率非常高，能够迅速清除与疾病相关的物质，保护机体免受伤害。 FcγR …