Two main ALDH enzymes metabolize the acetaldehyde produced during ethanol oxidation (see Table 3) (Crabb et al. 2004; Hurley et al. 2002): ALDH1, which is found in the fluid filling the …

2021年8月1日 · In this study, we asked if spinal ALDH2 regulates ethanol metabolites and the ethanol-induced analgesic effect in mice. We tested this hypothesis by performing various in …

2021年3月22日 · Jin et al. show that astrocytic ALDH2 metabolizes ethanol in the brain, thereby attributing behavioural effects of alcohol to metabolites produced in the brain rather than the liver.

2013年5月21日 · Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that metabolizes ethanol and toxic aldehydes such as 4-hydroxy-2-nonenal (4-HNE). Using an …

Ethanol metabolites such as acetate, thought to be primarily the result of ethanol breakdown by hepatic aldehyde dehydrogenase 2 (ALDH2), contribute to alcohol's behavioural effects and …

2022年6月13日 · 该研究启示 星形细胞aldh2可能是治疗酒精中毒的有用靶点，可通过调控星形胶质细胞aldh2表达，以助力解酒、戒酒，以及酒精诱发的脑损伤、退化的预防与治疗。同时， …

2018年10月12日 · ALDH2 deficiency inhibits ethanol protection by producing 4-HNE-SIRT1 adducts. 4-HNE-SIRT1 blocks the translocation of SIRT1 from the cytoplasm to the nucleus. …

2024年6月20日 · Alcohol dehydrogenase (ADH) is responsible for transforming ethanol into a toxic intermediate byproduct, acetaldehyde (AcH). Then, aldehyde dehydrogenase ALDH, …

1997年5月15日 · Mitochondrial aldehyde dehydrogenase (ALDH2) is a tetrameric enzyme that catalyzes the oxidation of acetaldehyde to acetate during ethanol metabolism. Approximately …

Aldehyde dehydrogenase (ALDH) detoxifies acetaldehyde into acetate. Subpopulations of Asians and Native Americans show polymorphism with loss-of-function mutations in ALDH2. We …