2025年3月30日 · ERLIN1 (ER Lipid Raft Associated 1) is a Protein Coding gene. Diseases associated with ERLIN1 include Spastic Paraplegia 62, Autosomal Recessive and Juvenile Amyotrophic Lateral Sclerosis. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Disorders of transmembrane transporters.

Erlin-1 (Endoplasmic Reticulum lipid raft-associated 1) is a protein encoded by the ERLIN1 gene in humans. [5] [6] [7] ERLIN1 and its homolog ERLIN2 are ER-localized members of the stomatin/prohibition/flotillin/HflKC (SPFH) family of proteins. They form a complex that functions to scaffold lipids and proteins. [8]

关于 erlin1 Cytogenetic location: 10q24.31 Genomic coordinates (GRCh38): 10:100,150,094-100,186,029 (from NCBI) This gene has 3 transcripts (splice variants), 196 orthologues, 1 paralogue and is associated with 2 phenotypes.

2021年9月13日 · ER lipid raft-associated protein 1 (ERLIN1) and 2 (ERLIN2) are 40 kDa transmembrane glycoproteins belonging to the family of prohibitins, containing a PHB domain. They are generally localized in the endoplasmic reticulum (ER), where ERLIN1 forms a heteroligomeric complex with its closely related ERL …

2025年2月9日 · The erlin1/erlin2 complex binds to and stabilizes phosphatidylinositol 3-phosphate and regulates autophagy. The common p.Ile291Val variant of ERLIN1 enhances TM6SF2 function and is associated with protection against MASLD.

A single-nucleotide polymorphism in ERLIN1 (p.Ile291Val) emerged as a potential gain-of-function mutation with a protective effect against MASLD development. The liver protective effects were only apparent in TM6SF2 p.Glu167Lys non-carriers and suggest an interesting interplay between ERLIN1 and TM6SF2.

在这项研究中，我们首次提供了内质网脂筏相关蛋白 1 (Erlin1) 是苦参碱的新靶点。 Erlin1 在肿瘤中显着上调，其敲低抑制了 CRC 细胞的增殖和迁移，而其过表达促进了 CRC 细胞的生长和迁移。

2024年3月8日 · ERLIN1 （ER lipid raft-associated 1）是一种跨膜蛋白，在内质网的物质运输和内质网相关线粒体蛋白复合体（ERMES）的形成中起重要作用。 ERLIN1属于ERLIN家族，是一个高度保守的蛋白家族，在哺乳动物中高度表达。

2024年2月4日 · Clinical resource with information about ERLIN1, A genome wide association study (GWAS) providing evidence of an association between common genetic variants and late radiotherapy toxicity., Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans., Hereditary spastic paraplegia 62 ...

2024年5月24日 · Complexes of ERLIN1 and ERLIN2 (ER lipid raft-associated 1 and 2) form large ring-like cup-shaped structures on the endoplasmic reticulum (ER) membrane and serve as platforms to bind cholesterol and E3 ubiquitin ligases, potentially defining functional nanodomains. Here, we show that ERLIN scaffolds …