Combating acquired resistance to MAPK inhibitors in melanoma …
2020年10月29日 · Here, we demonstrate that ABL1/2 kinase activities and/or expression are potentiated in cell lines and patient samples following resistance, and ABL1/2 drive BRAF and …
High Expression of ABL2 Suppresses Apoptosis in Gastric Cancer
Puromycin was used to maintain the stable low expression of ABL2 MGC-803 cells compared with control cells; what is more, the high expression of ABL2 BGC-823 cells was also obtained. …
ABL1/2 and DDR1 Drive MEKi Resistance in NRAS-Mutant …
2023年2月2日 · In some acquired resistance cells, ABL1/2 and DDR1 cooperate to stabilize RAF proteins, activate ERK cytoplasmic and nuclear signaling, repress p27/KIP1 expression, and …
ABL2在胃上皮细胞GES-1中对PI3K/AKT及ERK通路蛋白和细胞功能 …
为了进一步研究abl2在胃部疾病发生发展进程中的作用及相关机制，本论文主要以正常胃上皮细胞（ges-1）为主要研究对象，探究abl2的异常表达对ges-1细胞的增殖、转移能力的影响及可能 …
High Expression of ABL2 Suppresses Apoptosis in Gastric Cancer
2018年5月16日 · All the data showed that high expression of ABL2 suppresses apoptosis through Ras/Erk and PI3K/AKT signaling pathway in GC cell lines. Diseases associated with Abelson …
ABL2 expression affected apoptosis, PI3K/AKT signaling, and Ras/Erk …
Importantly, miR-30a-5p was demonstrated to target and downregulate ABL2, subsequently inactivating the PI3K/AKT pathway. miR-30a-5p inhibited the malignant phenotypes of LUAD …
Abl kinase regulation by BRAF/ERK and cooperation with Akt in
2017年4月3日 · Here we elucidate a novel link between BRAFV600E/ERK signaling and Abl kinases. We demonstrate that BRAFV600E/ERK play a critical role in binding, phosphorylating …
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
2025年2月19日 · ABL2/ARG is a novel mediator of SEMA3F-induced RhoA inactivation and collapsing activity. The highest Arg transcript and protein levels are in the mature B cells. The …
Combating acquired resistance to MAPK inhibitors in melanoma …
2020年10月29日 · Here, we demonstrate that ABL1/2 kinase activities and/or expression are potentiated in cell lines and patient samples following resistance, and ABL1/2 drive BRAF and …
The Emerging Role of ABL Kinases in Solid Tumors - PMC
Recently, the ABL family kinases, ABL1 and ABL2 (also known as Abl-related gene, Arg) have been shown to play a role in the progression of several solid tumors through activation …
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