Enalapril is an antihypertensive agent that exhibits natriuretic and uricosuric properties. Enalapril lowers blood pressure in all grades of essential and renovascular hypertension, and peripheral vascular resistance without causing an increase in heart rate. 6 Individuals with low-renin hypertensive population were still responsive to enalapril.

2019年11月24日 · Enalaprilat is the active metabolite of the oral prodrug enalapril maleate. Enalaprilat is poorly absorbed orally and requires intravenous administration. It inhibits angiotensin I to angiotensin II conversion via competitive inhibition …

2024年9月17日 · Enalapril is utilized in asymptomatic left ventricular dysfunction as it mitigates progression to symptomatic heart failure and reduces mortality. Enalapril maleate is a prominent angiotensin-converting enzyme inhibitor approved by the US Food and Drug Administration (FDA) for the treatment of heart failure, chronic hypertension, and ...

When given with hydrochlorothiazide, enalapril attenuates the secondary aldosteronism and ameliorates the hypokalaemia from diuretics. 3 Both acutely and chronically in patients with essential hypertension, enalapril reduced blood pressure with a rather flat dose-response curve.

Enalapril increased renal blood flow, glomerular filtration rate and sodium excretion. The mechanism of the natriuresis in dogs probably involves several mechanisms including a decrease in aldosterone biosynthesis, changes in renal function (glomerular filtration rate and renal blood flow) and possibly blockade of a direct tubular effect of AII ...

Enalapril is an orally-active and long-acting nonsulphydryl antihypertensive agent that suppresses the renin-angiotensin- aldosterone system to lower blood pressure. It was developed from a targeted research programmed using molecular modelling.

Enalaprilat is the active metabolite of the orally available pro-drug, enalapril. Used in the treatment of hypertension, enalapril is an ACE inhibitor that prevents Angiotensin Converting Enzyme (ACE) from transforming angiotensin I into angiotensin II.

2024年2月13日 · Enalapril maleate is a prominent angiotensin-converting enzyme inhibitor approved by the US Food and Drug Administration (FDA) for the treatment of heart failure, chronic hypertension, and asymptomatic left ventricular dysfunction. The FDA has approved a fixed-dose combination of enalapril with hydr …

Enalapril maleate is an orally active angiotensin-converting enzyme inhibitor. It lowers peripheral vascular resistance without causing an increase in heart rate. Enalapril 10 to 40 mg/day administered either once or twice daily is effective in lowering blood pressure in all grades of essential and …

Enalapril. Class: ACE-inhibitor Chemistry: L-proline derivative with dicarboxylate (-COOH) group. Routes of administration: Oral. Absorption: 60% oral bioavailability. Solubility: pKa 3. Distribution: unknown. Metabolism: 60% hepatic metabolism. Elimination: 40% renally excreted unchanged. Time course of action